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ID:32187911
大小:3.49 MB
页数:67页
时间:2019-02-01
《利多卡因微乳凝胶外用制剂的制备与药效学评价》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、万方数据浙江大学硕士学位论文lidocaineisthepreparationoftransdermaldrugdeliveryformulationssuitable.2.Theoptimumformulationoflidocainemicroemulsion:lidocainecontentis2%,ethyloleatewas4%,Twain-80Was15%,for9%ofanhydrousethanol,deionizedwateriS70%.Invitrooptimalformula
2、tionoflidocainemicroemulsionreleasingperformanceisgood,thesizeofmicroemulsionareabout40nto,transmissionelectronmicroscopyshowedsphericaldroplets,stabilitystudyshowedthemicroemulsionpreparationwasstable.3.ThroughscreeningtodeterminethegelmatrixforCarbo
3、pol940,theoptimalprescriptionoflidocainemicroemulsiongel:Carbopol940wasO.5%,thecontentoflidocaine2%,ethyloleatewas4%,Twain-80was15%,for9%ofanhydrousethanol,deionizedwateris69.5%.Optimalmicroemulsiongelformulationofpreparationsinvitroreleasebehaviornea
4、rzeroorderrelease,physicochemicalpropertiesandstabilityofthepreliminaryinvestigationresultsshowthatthephysicalandchemicalpropertiesandstabilityofthepreparationweregood.4.Theanalgesicexperimentsshowthat,inlow,highdose,themicroemulsiongelCandosedependen
5、tlyincreasedthepainthresholdofmice,andinthesamedosage,microemulsiongel,highdosesof45minand60minintheblankcontrolgroup,with2%lidocainegelgroup,solutionof2%lidocainegroupwerestatisticallysignificant(P<0.05),theseresultssuggestthattheanalgesiceffectofmic
6、roemulsiongel,highdosethangelgood.Theskinirritationtestresultsshowthat,thehighdoseofmicroemulsionwithmildirritationtonormalintactskin,microemulsiongelhighdosetonormalintactskinwithoutirritation,butmicroemulsionandmicroemulsiongel、析tllhighdosetothebrok
7、enskinwithmildstimulation,suggestingthatlidocainemicroemulsiongelhasgoodsafety.Conclution:Lidocainemicroemulsiongelhastheadvantagesofsimplepreparationprocess,easycoating,smallparticlesizeanduniformdistributionoflocalanesthesia,showedbetteranalgesiceff
8、ectandgoodsafety,developingitasalocaltransdermaldrugdeliverysystemhascertainvalueinclinicalapplication.Keywords:Lidocaine;microemulsion;gel;pseudo—temaryphasediagram;transdermaldelivery;AnalgesiaV万方数据浙江大学硕士学位论文缩写、符号清单、术语表VI万方数据浙江大学硕士学位论文目录目录致谢
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