本科生毕业论文奥沙普秦速释滴丸研制与市售肠溶片溶出度考察.pdf

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1、本科生毕业论文奥沙普秦速释滴丸研制与市售肠溶片溶出度考察2007年6月4日目录摘要..................................................................3Abstract................................................................4第一章综述..........................................................51非甾体抗炎药—奥沙普秦...................................

2、.........51.1奥沙普秦的理化性质...........................................51.2奥沙普秦的药理作用与药动学性质..............................51.3奥沙普秦的剂型研究现状.......................................52滴丸剂的研究现状..................................................62.1滴丸成型理论.................................................62.2滴

3、丸剂的基质与冷凝液.........................................62.3滴丸剂的生产工艺和质量控制..................................72.4滴丸剂的特点.................................................72.5滴丸剂的种类.................................................72.6中药滴丸.....................................................83体外溶出度研究动态.

4、...............................................84论文立题依据......................................................9第二章奥沙普秦速释滴丸制备.......................................101仪器、药品与试剂.................................................102实验方法..........................................................112.1

5、紫外分析方法的建立..........................................112.1.1溶液配制..............................................112.1.2最大吸收波长的确定....................................112.1.3线性关系及范围考察....................................112.1.4回收率试验............................................112.1.5溶液稳定性考察..........

6、..............................112.2滴丸制备....................................................1112.3圆整度和丸重差异测定........................................122.4滴制条件优化................................................122.5处方剂量优化................................................122.6含量均匀度测定...............

7、...............................122.7溶出度测定..................................................123结果与讨论........................................................133.1紫外分析方法的建立..........................................133.1.1最大吸收波长的确定.....................