呼吸道细菌定植对毛细支气管炎患儿预后与转归的影响

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1、Result：71％ofthe480casesdiagnosedasbronchiolitisweremen，andwomenaccountfor29％．Theonsetagewasbetween1and19months，theaverageageof5．29土3．39months．ThepeakseasonofbronchiolitiswasonNovemberandDecember．Bacterialcolonizationinrespiratorycasesaccountedfor55．83％ofallcases，mainlytobeGram。ne

2、gativebacteria，accountingfor67．16％，includingHaemophilusparainfluenzae，KlebsiellapneumoniaeandEscherichiacolibacteriaetc．Thetotalofvirusinfectionwas313cases，accountingfor65．21％ofallcases，includingrespiratorysyncytialvirusinfectionin288cases，accotmtingfor92．01％．Othervirusesincluded

3、parainfluenzavirusinfectionin10cases，1caseofinfluenzavirusinfection，adenovirusinfectionin2cases．Bothofvirusandbacterialdetectedpositivewasaccountedfor36％oftheproportionofallchildren．TheseverityanddurationoftheRSV+B+groupwashigherthantheRSV+B—group(P

4、oupwashigherthantheRSV-B—group(P<0．01)．CaseswithRSVdetectedpositiveweremoreseriousthanthatRSVdetectednegative(P

5、weenthesegroups．Follow-upresultsshowedthatthepercentageoftheRSV+B+group一5一重庆医科大学硕士研究生学位论文withrecurrentwheezingwas42％，whichwashigherthantheRSV+B-group(36％)．ComparedwiththeRSV+B-group，theRSV-B—wasmorelikelywithrecurrentwheezing．Atthesametime，wheezingwasmorelikelyinducedbytherespira

6、torytractinfection．Conclusion：Airwaybacterialcolonizationintheinfantswithviralinducedwheezingmightincreasetheseverityandextendthecourseofdiseasewithasthmaticdisease，whileincreasedtheriskofwheezingwithinoneyearaftertherecurrence．Non-RSVvirusesmightbemorelikelycausetheoccurrenceofr

7、ecurrentwheezinginchildren．Keywords：Bacterial，Respiratorysyncytialvirus，Colonization，Asthma，Recurrentwheezing一6一■■FP‘r’，P_▲_-—Pl}-：；l-¨l--lIll●-一llLo}重庆医科大学硕士研究生学位论文呼吸道细菌定植对毛细支气管炎患儿预后与转归的影响-▲上-_Jo刖昌由于婴幼儿气道发育特点，喘息性疾病是婴幼儿呼吸道疾病中最常见的疾病之一，病毒感染是引起婴幼儿喘息最常见原因，其中RSV是导致毛细支气管炎(以下简称毛支炎)最常见的病

8、原体。相较于未患毛支炎的同龄婴幼儿，毛支炎患儿在学龄期肺功能相对降低，更容易发生