mrs和pwi在脑转移瘤中的应用研究——诊断及伽玛刀疗效评价

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1、天津医科大学硕士学位论文Abstract——、ApplicationofMRSandPWIindiagnosisofbrainmetastasisobjeetive：AnalyzetherelationshipbetweentumorvolumeandCho／Cr,tumorvolumeandrCBV,Cho／CrandrCBV．ExploretheapplicationvalueofMRSandPWIinthediagnosisofbrainmetastasis．Methods：Collect56lesions州SCLC43，b

2、reastcancer13)of47patientsofuntreatedbrainmetastasis(NSCLC37，breastcancer13)fromMay2010toOctober2012inthehospital．AlllesionswerescannedbycMRIandMRS，and16ofwhichwere(NSCLC11，breastcancer5)alsoscannedbyPWI．Measurethelen舀handthewidthofthetumorontheaxialplane，andtheheight

3、onthecoronalorsagittalplane，andthetunqorvolumewasthencalculatedaccordingtotheEllipsoidcubatureformula(V=彬6×length×widthxheight)．ProcessMRSandPWIdatausingFunctoolsoftware，selectthemaximumtumorCho／Cr,measurandcalculatnormalizedrCBVratios(rCBVnor=rCBVwithinthetumor／avera

4、gerCBVinthecontralateralnormalappearingwhitematter)．AnalyzetheCho／CrandnormalizedrCBVbetweentwodifferentsourcesofmetastasisbyt-testoftwoindependentsamples，andexaminethecorrelationbetweeneachtwoofCho／Cr,normalizedrCBV,andtUlTIOrvolumeusingthePearsoncorrelationtestanaly

5、sis．Results：MRSandPWIdataofbrainmetastasisderivedfromNSCLCandbreastcancerwerestatisticallyanalyzedresultsasfollows：1．Cho／CrandnormalizedrCBVwerenotstatisticallydifferent俨一0．971，0．932)；2．ThecorrelationbetweenCho／Crandtumorvolumehasstatisticalsignificance(Pearsoncorrela

6、tioncoefficient-0．369，P=0．005)，butnocorrelationbetweennormalizedrCBVandtulIlorvolume(Pearsoncorrelationcoefficient=0．443，P=0．085)；3．Cho／CrandnormalizedrCBVwashi曲lycorrelated(Pearsoncorrelationcoefficient=0．884，P<0．001)．Conclusions：Thepositivecorrelationsexistbetweentu

7、lTIorvolumeandCho／Cr,Cho／CrandrCBVinbrainmetastasis．MRSandPWIcouldreflectthetunlorcellmetabolismandangiogenesis．thecombinationofthetwoalongwiⅡlcMRIcouldimproveandcompletediagnosisofbrainmetastasisfurther．二、MRS-basedGKStreatmentefficacyanalysisofbrainmetastasisIII天津医科大

8、学硕士学位论文objective：AssesstheefficacyofGKSbydetectingthemetabolitelevelschangesofbrainmetastasisbeforeandaftertreatmentbyMRS，th