丙戊酸对人卵巢癌a2780细胞生长与血管生成和转移相关因子表达影响的分析

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1、／坐奎查兰堡主兰垡丝苎apoptosisratewenthigherasthetreatmenttimeprolonged，therewasthesignificantdifferencefordifferenttime(尸

2、F、MMP-9、MMP一2incellstreatedwithVPAataconcentrationof3mmol／lfor48h，andincreasedproteinexpressionofE．cadherin．Thedifferencewithcontrolswassignificant(P<0．oi)．FlowcytometricanalysisrevealedthatFIsofVEGF、MMP一9、MMP-2experimentalgroupwereO．4391士0．0136、0．6187+0．0066、0．5086士0．0557，andweresignificantlylesst

3、hanthatofthecontrolgroup(1．00+0．0193、1．00+0．013、1．00士0．0308)，thedifferencewassignificant(P

4、ferationofhumanovariancarcinomacelllineA2780cellinvitro．Inducingapoptosis，cellcycleGIphasearrest，downregulatingtheexpressionofVEOF,MMP-9，MMP-2andupregulatingtheexpressionofE·cadherinwhichappeartobeamechanismforthegrowthinhibitionofVPA-treatedA2780cellline．DownregulationofVEGF,MMP一9，MMP一2andupregula

5、tionoftheexpressionofE-cadherinindicateVPAmayhaveffectofinhibitingangiogenesisandmetastasisoftumors．KeywordsOvarianneoplasms；Valproicacid；Vascularendothelialgrowthfactor(VEGF)；Martixmetalloproteins(MMPs)；E—cadherin；Apoptosis6山东人学硕十学停论文缩写A2780BMCAMsE．cadherinECMFCMfltHDACHDACIHEmgmlnmlMMPsMTTPIPBSVE

6、GFV队VPF英文中英文对照basementmembranecelladhesionmoleculesepithelialeadherinextracellularmatrixflowcytometryfms-liketyrosinekinasereceptorhistonedeacetylasehistonedeacetylaseinhibitorhematoxylineosinmilligramminutemillilitermartixmetallOprOteins3一(4，5dimethylthiazol一2-y1)-2,5-dipenylterazoliumbromidepropo

7、diumiodinephosphatebuffersalinevascularendothelialgrowthfactorvalproicacidvascularpeemeabilityfactor7中文卵巢上皮癌细胞株基底膜细胞粘附分子上皮性钙黏附素细胞外基质流式细胞技术fins样酪氨酸激酶受体组蛋白去乙酰化酶组蛋白去乙酰化酶抑制剂苏木素伊红染色毫克分钟毫升基质金属蛋白酶类四甲基偶氮唑蓝碘化丙啶磷酸盐缓冲