阿托伐他汀对急性st段抬高性心肌梗死患者尿激酶溶栓疗效的影响

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1、treatment、thechangesofhs—CRPbeforeandaftertreatment，andfollow—upofthelevelofincidenceofcardiovasculareventsin1month．Results：1Comparedwiththecontrolgroup，thetimeofChestpainreliefwerenotdifferent(1．3+0．2hVS1．4+0．3h，P>O．05)，STsegmentfellwerenotdifferent(

2、1．0士O．4mvVS0．9i0．3mv，P>O．05)，thepeakofenzymeappearaheadoftime(12．4J：1．3hVS13．3+1．7h，P

3、thecontrolgroup，thevalueofhscrpwasnodifferencebeforetakingthemedicine(3．10-士0．36mg／LVS3．17+0．40mgm，P>0．05)，oneweeklater，thevalueofhscrpreducedsignificantly(2．32_-k0．28mg／LVS3．88+0．29mg／L，P

4、．02士0．32mgmVS2．97士0．28mgm，P<0．05)．3Onemonthoffollow-up，comparedwitllthecontrolgroup，theincidenceofpostinfarctionangina(7．7％VS9．3％)；theincidenceofheartfailure(12．8％VS14％)；theincidenceofagainrecurrentmyocardialinfarctionincidence(5．1％VS7．0％)；theincidenc

5、eofarrhythmia(15．4％VS14％)；theincidenceofcardiacdeathincidence(5．1％VS6．9％)，Allwerenotsignificantlydifferent(p>0．05)．Conclusion：1Theinitialloadingdose(80mg)ofatorvastatinCanimprovethrombolyticrecanalizationrates，reducecoronaryarteryopeningtime，suggestin

6、gthattheinitialloadingdose(80mg)ofatorvastatinbeforethrombolysiscansignificantlyimprovethethrombolyticefficacy；2Theinitialloadingdose(80mg)ofatorvastatinCansignificantlyreducethelevelsofhsCRP．suggestingthatitcanreducetheinflammationreactioninthebody．3

7、Onemonthoffollow-up，cardiovasculareventsshowednodecline，suggestingthattheinitialloadingdose(80mg)ofatorvastatinbeforethrombolysisisnosignificantbenefittoonemonthofcardiovasculareventsforpatientswithSTEMI．KeyWords：atorvastatinacuteST—segmentelevationmy

8、ocardialinfarctionthrombolytictherapyUrokinase4阿托伐他汀对急-I'$ST段抬高性心肌梗死患者尿激酶溶栓疗效的影响硕士生姓名：指导教师：专业名称：陈德春王虹艳教授心血管内科学月IJ吾他汀类药物已经被广泛地应用于心血管疾病的治疗，通过降低低密度脂蛋白(LCL．C)改善心血管疾病的预后，同时他汀类药物还具有抗炎、抗氧化、改善内皮功能、抗血小板聚集和抗血栓形成等较快的调脂外的心血管保护效应【lj。他汀药物的抗炎作用与剂量相关【2】，大剂量才能