阿尔茨海默病静息态脑网络内与网络间功能异常

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1、AbstractObjective：rhisstudYcombinedmultipleimagingmodalitiestoinvestigatethef．unctional觚dstmcturalchangeswithineachresting—statenetwork(RSN)andbe骶enRSNsinpatientswithamnesticmildcognitiveimpairment(aMCOorAlzheimer，sdisease(AD)．SubjectsandMethods：A幻tal

2、of87oldersubjectswererecruitedinthisstudy．CognitivefunctionwaseValuatedwiththemini‘mentalstateexamination(MMSE)，andthedegreeofdementlawasdeterminedbytheclinicaldementiaratingscale(CDR)．ThirteensubjectswereexcludedduetoexcessiveheadmotionduringMRscamin

3、gorpoor1magequality·Intotal，74subjects，including21NC，18aMCI，and35AD．wereincludedinthefurtheranalyses．Resting．statefunctionalmagneticresonanceimaging(fMRI)scanandstructuralimagingwereperformedusinga3．0TSignaMRscanner(MagnetomTrio，Siemens，Germany)．Durin

4、gfMRISCanS，allsubjectswereinstructedtokeeptheireyesclosed，tostayasmotionlessaspossible，tothinkofnothinginparticular，andnottofallasleep．ThefMRIdatawereanalyzedusin2theDataProcessingAssistantforResting．StatefMRI(DPARSFA)．Voxel．basedmo印homet巧(VBM)analysi

5、swasperformedusingStatisticalParametricMapping(SPM8，http：／／www．fil．ion．ucl．ac．uk／spm／sofiware／spm8)basedonMatlab．Thepreprocessingofrs-fMRIdataincludingslicetiming，realignment，spatialnormalizationtotheEPItemplate，resamplingto2-ram3voxels，aband—passfreq

6、uencyfilter(0．01-0．08Hz)andsmoothedwitha4mmfull．widthathalf-maximum(FWHM)Gaussiankemel．Finally,individualALFFmapsweregeneratedbycalculatingthesquarerootofthepowerspectrumateachfrequencyandaveragedacrossO．01—0．08HzforeachvoxelbytheDPARSFAsoRware．RSNswe

7、reidentifiedfromfMRIdatausingthegroupindependentcomponentanalysis(GICA)ofthefMRItoolbox(StableandConsistentGroupICAofthefMRIToolbox，version1．2；http：Hwww．nitre．org／projects／cogicat／)．Thepreprocessingofhighresolutionstructuraldataincludingsegmentationof

8、grayandwhitematter，Ill天津医科大学硕士学位论文spatialnormalizationandsmoothwithaF’WHMkemelof4mlTl．Thefunctionalnetworkconnectivity(FNC)wascomputedforeachpairofthe8RSNs．Fortheintra-networkanalyses，wefirstcomparedtheintra-networkFCsamongthethreegroupsinavox