comt基因多态性对脑结构及功能调控的多模态mri研究

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1、万方数据天津医科大学硕十学位论文强度；这可能是由于不同人群中COMT活性差异导致部分脑区多巴胺浓度不同而引起的。2．COMTVail58Met基因多态性对默认网络脑区结构及功能的调控是相对独立的过程，不存在直接关联性。3．COMTVall58Met基因多态性对前额叶形态的调控具有性别依赖性。4．COMT与DRD2基因多态性对大脑功能连接密度的调控具有系统依赖性。关键词：COMTDRD2多巴胺脑功能网络性别体素形态学分析功能磁共振成像III万方数据天津医科大学硕士学位论文AbstractObjective：TheeffectofCOMTVail58Metpolymorphismonbrainst

2、ructureandfunctionhasbeenpreviouslyinvestigatedseparatelyandregionally．TheinteractionsbetweenCOMTandgenderorbetweenCOMTandotherdopaminergicsystemrelatedgenesneedsystematicallyinvestigation．WeexaminedalargesamplesizeofhealthyyoungadultsandanalyzedboththeGMV,rsFC，andFCDdifferencesbetweengeneticgroupsi

3、navoxel—wisemannerthroughoutthewholebrain．SubjectsandMethods：Atotalof323healthy，young，right—handedsubjectswererecruited．Resting--statefMRIandhigh--resolutionstructuralimagingwereperformedusingaGE3．0TSignaHDXscanner．1．WegenotypedtheCOMTrs4680andDRD2rsl076560ineachsubjectusingthePCRandLDRmethod．2．Allp

4、reprocessingstepswerecarriedoutbasedonMatlab．Thepreprocessingofhighresolutionstructuralimagesincludingsegmentationofgreyandwhitematter，spatialnormalizationandsmooth；whilethepreprocessingofresting—statefMRIdataincludingslicetiming，realignment，spatialnormalization，resamplingandsmooth．IndividualFCDmaps

5、weregeneratedbycalculatingFCDbeforesmoothing．Theobtainedlocalandlong-rangeFCDweregrandmeanscaledtoincreasethenormaldistribution．Finally,theFCDmapsweresmoothed．3．VBManalysisofstructuralMR[datawasperformedtoinvestigategroupdifferencesofGMV．ThenweextractedthesebrainregionswimGMVdifferencesasseedstocomp

6、utersFCwiththerestofthebrain．4．Consideringthepossibleinfluenceofgender，age，andeducationleval，weexploredtheimpactofCOMTandDRD2polymorphismsontheFCDs．5．Atwo—wayanalysisofvariance(ANOVA)wasusedtoevaluatethemaineffectsandinteractions，withmultiplecomparisonscorrected．Results：1．Thegenotypedistributionsoft

7、heSNPswereinHardy—Weinbergequilibrium．Ⅳ万方数据天津医科大学硕士学位论文2．ANOVArevealedasignificantmaineffectofCOMTonGMVintherightposteriorcingulatecortex(pcc)．Post—hoctestingshowedthatValhomozygotesexhibitedsignifica