胃肠间质瘤组织中mmp-9与hpa表达与螺旋ct征象的相关性.研究

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1、郑州大学2009届硕士学位论文胃肠间质瘤组织中MMP一9及HPa表达与螺旋cT征象的相关性研究StudyontherelationshiPbetweenPiralCTfeaturesandtheexPressionofMMP·9andHPainGastrointestinalStromal毛lmorCandidateforIlasterXuChlinlliaosuPervisorChenKuishengGaoJjianboThebasiemediealeollegeofZhengZhouUniversity，

2、thePathologydePartmentZhengZhou450052AbstractGIST(Gastrointestinalstromaltumors)aremesenchymaltumorwithhighexPressionofCDll7ofsPindle，ePithelioidorallomorphiceellsinadditiontogastrointestinalsmoothmuscletumors，sehwannomaandneurofibroma.Westillean’tgetconsis

3、tentunderstandingduetotheireomPlexity，whiehbringsalotofineonvenieneetothediagnosisandtreatment.SPiralCTeandeteetmoremalignancysignsofGIST，thusitPutanimPortantguidingvaluesonitsearlydiagnosisandtreatmentaswellasPrognosis.SincethemajorityofGISTexPressCDll7and

4、CD34，someseholarsthinkitoriginatedinthegastrointestinaltraetCajaleellwall(interstitialeellsofcajal，ICc).CDll7Protein(C一KITProtein)15atransmembranereeePtorProteinoftyrosinekinase，belongingtoC一KJTProto一oncogeneProteinProduet，exPressedinhematoPoietiestemeellsu

5、bsets，masteells，melanomaeellsandthegastrointestinaltraetoftheCajalmesenchymalcells.ManyscholarshavebeenrePortedtheyhadfoundCDll7exPressioninGISTandregarditasasignofitsimmunePhenotyPe.CD3415glyeosylationProteinandahematoPoietieProgenitoreellantigenwhieh15ear

6、lieraPPliedtostudyGIST.Initiallyithasbeendeteetedinstromaltumors，andahigherexPressionrateinGIST.MMP一9areanimPortantProteaseindegradationoftyPeIVcollagen，andPlayanimPortantrolelnextraeellularmatrixdegradation，invasionofsurmundingOrganizationsforthetumoreells

7、.Atthesametime，itaffeetstumorvaseularangiogenesisasthenumberofvaseularstarting郑州大学2009届硕士学位论文胃肠间质瘤组织中MMP一9及HPa表达与螺旋CT征象的相关性研究system.Researehesfoundthatindifferenttumortissuessuehasmalignantmelanoma，endometrialeancer，ProstatecancerandPrimarybraintumors，MMP一9

8、aetivationand(or)exPressionhasagoodeorrelationwithmalignantdegreeand(or)metastasis.HeParansulfateProteoglyean(HSPG)areacomPlexbiologiealmacromoleeuleswidelyexistintheveriebrateextraeellularmatrix(extra