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ID:32008269
大小:1.31 MB
页数:38页
时间:2019-01-30
《何首乌不同剂量和大鼠肝损伤程度实验的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、陕西中医学院硕士学位论文何首乌不同剂量与大鼠肝损伤程度的实验研究姓名:耿增岩申请学位级别:硕士专业:中药学指导教师:胡锡琴20070501何首乌不同剂量与大鼠肝损伤程度的实验研究摘要目的:本课题通过长期灌服大鼠不同剂量的制何首乌水煎浓缩液,旨在探求观察制何首乌不同剂量与大鼠肝损伤程度的相关性,初步建立何首乌量一毒关系及肝脏损害程度标准。为临床安全用药提供依据,使何首乌临床应用合理、安全、有效,使何菪乌被更加充分利用,更有效地造福人类,以促进中药更好的进入国际医药市场,对中药现代化建设具有现实意义。方法:急毒试验测得小鼠晟大给药量为3609/kg。以相当于成人每目临床用量的20、50、100、2
2、00倍连续灌胃给大鼠3个月,观察受试大鼠的一般情况、体重、血液生化指标及主要组织器官的形态学、病理学改变,重点观察肝组织、肝细胞超微结构的变化以及停药恢复1个月后上述指标的恢复情况。结果:给药期间,各剂量给药组大鼠的体重增长与食水摄入量较对照组没有显著性差异。大鼠3个月血液生化指标检测,示大剂量组AsT显著性升高(PO.05)。3个月时,肝组织匀浆检测表明,大剂量组MDA有显著性增高(P3、、较大剂量给药组肝窦内皮细胞肿胀,核内染色质凝集或边集于核膜下,线粒体肿胀,毛细胆管扩张。其它给药组不明显。心电图结果显示正常,脏器指数各给药组与对照组比较均无显著性差异(P>O.05)。结论:制何首乌长期大剂量灌胃对大鼠肝脏有一定的损伤,损伤程度与其剂量大小有一定的相关性,属可逆性损伤。关键词:制何首乌;肝脏;长期毒性;相关性TheexperimentaIstudyofdifferentdosageofHeShouWuoRrats’hepaticinjuryAbstractObjeetive:toexplorethedegreeofhepaticinjurywhichprocessedHeS4、houWucancausetoratsandwhetherthereisdosagecorrelationafterlong—termoralprocessedHeShouWudecoctedinwaterintoconcentration,thustodiscussthemechaniSilltoprovideafoundationfortheclinicaldrug—use.Methods:acutetoxicitytestwascommitted,andthemaximumtolerateddose(MTD)is3609/kg.ReferingtoMTD.Excepttocontrolg5、roup,higherdosegroup、highdosegroup、middledosegroup、]owerdosegroupwereadministeredprocessedHeShouWusuccessivelyfor3monthswithdosageequivalentto200、100、50、20timesofhumanclinicaldosagetoobservethegeneralcondition、weight、indexesofbloodbiochemistryinratsandthemorphologicalchangeofmainorganandtissue,theul6、trastructureofhepatictissueandcellwhichisregardedasemphasisduringadministrationandrestorationperiods.RosuIts:Therats’weightofdifferentdosesgroupdidn'thasobviouslvdifferenceafteradministrationforsomeperiodscomparedwithcontrolgroup.higherdosegroup,AST、∞Aincreaserespectivelywhen3“monthofadministration.7、Lightmicroscopeandelectronmicroscopeshowedthathigherdosegroupandhighdosegrouphasdifferentpathologicalpresentationcomparedwithcontrolgroup.theresultofECGandorganindexisnormal.Oonclusion:processedHeShou
3、、较大剂量给药组肝窦内皮细胞肿胀,核内染色质凝集或边集于核膜下,线粒体肿胀,毛细胆管扩张。其它给药组不明显。心电图结果显示正常,脏器指数各给药组与对照组比较均无显著性差异(P>O.05)。结论:制何首乌长期大剂量灌胃对大鼠肝脏有一定的损伤,损伤程度与其剂量大小有一定的相关性,属可逆性损伤。关键词:制何首乌;肝脏;长期毒性;相关性TheexperimentaIstudyofdifferentdosageofHeShouWuoRrats’hepaticinjuryAbstractObjeetive:toexplorethedegreeofhepaticinjurywhichprocessedHeS
4、houWucancausetoratsandwhetherthereisdosagecorrelationafterlong—termoralprocessedHeShouWudecoctedinwaterintoconcentration,thustodiscussthemechaniSilltoprovideafoundationfortheclinicaldrug—use.Methods:acutetoxicitytestwascommitted,andthemaximumtolerateddose(MTD)is3609/kg.ReferingtoMTD.Excepttocontrolg
5、roup,higherdosegroup、highdosegroup、middledosegroup、]owerdosegroupwereadministeredprocessedHeShouWusuccessivelyfor3monthswithdosageequivalentto200、100、50、20timesofhumanclinicaldosagetoobservethegeneralcondition、weight、indexesofbloodbiochemistryinratsandthemorphologicalchangeofmainorganandtissue,theul
6、trastructureofhepatictissueandcellwhichisregardedasemphasisduringadministrationandrestorationperiods.RosuIts:Therats’weightofdifferentdosesgroupdidn'thasobviouslvdifferenceafteradministrationforsomeperiodscomparedwithcontrolgroup.higherdosegroup,AST、∞Aincreaserespectivelywhen3“monthofadministration.
7、Lightmicroscopeandelectronmicroscopeshowedthathigherdosegroupandhighdosegrouphasdifferentpathologicalpresentationcomparedwithcontrolgroup.theresultofECGandorganindexisnormal.Oonclusion:processedHeShou
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