巨噬细胞炎性蛋白1α(mip-1α)评价胰腺炎严重程度的-研究

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1、万方数据英文论著摘要Macrophageinflammatoryprotein1alpha(MIP·-1alpha)evaluationoftheseverityofacutepancreatitisObjectiveAcutepancreatitisisoneofcommonacuteabdomen，patientswithsevereacutepancreatitisafterdangerous20％一30％．Theoverallmortalityratewas5％一10％．Thepathogenesisoftheacutepancreatitisisinvolvedininflamma

2、tion，immunedisorders，microcirculationdisturbanceandapoptosisetc．MIP-1ccasoneofinflammatorymediators，thedevelopmentprocessisinvolvedinavarietyofdiseases，Suchasinflammation，immunityandinflammationrelateddiseases，suchastumor．However,theindexinacutepancreatitisclinicaldiagnosisisnotclear．Ouraimistodete

3、ctthebloodofpatientswithdifferentdegreeofacutepancreatitisinMIP-10【levels．ToprovidemoreevidenceforthediagnosisandprognosisofSAEMethodsTencasesofsevereacutepancreatitis(SAP)patients，twenty—sevencasesofmoderatelysevereacutepancreatitis(MSAP)andfifty-threecasesofnormalmildacutepancreatitis(MAP)weredia

4、gnosedintheFuxinmininggroupgeneralhospitalfromDecember2013toDecember2014，andanother10healthyvolunteersweresetasnormalcontrols．48hourswereselectedinacutepancreatitisandPhysicalexaminationcenterofGeneralHospitalofFuxinmininggroupofhealthyvolunteers4mlinvenousbloodsamplesanticoagulatedtube，Thensavethe

5、-70DEGCaftercentrifugation．TheuseofUSABioTekElx808automaticenzymeimmunoassayinstrument，TheexpressionofMIP．1otwasmeasuredbyELISAmethod，thevalueof．StatisticalanalysisusingExcelsoftwareandSPSS(V19．0)statisticalsoftware，statistical．TheMIP一1CLconcentrationofaexpressedbyX+S．Singlefactoranalysisofvariance

6、wasusedtocomparetheseindexesbetween．Thelinearcorrelationcoefficienttodescribetheassociationbetweentwoquantitativevariablesandthedirectionoftheclosedegree，TodeterminethesensitivityandspecificityofMIP一10【byROCcurve．BasedonP<0．05万方数据thedifferencewasstatisticallysignificant．ResultThePlasmalevelofMIP-ls

7、at48hinAPgroupwassignificantlyhigherthanthatinhealthycontrol(HC)group(t2O．845，P=0．045)，ItwasnomarkedlydifferentbetweeningroupofMAPandHCgroup(P>0．05)：MSAPandSAPgroupweresignificantlyhigherthanthatofHCgroup(P