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《stemi患者血清fgf21在急诊pci前后的动态变化与其与心功能相关性的临床-研究》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。
1、and3daysafteroperation,thetreatmentwerecollectedvenousblood4mlintothecoagulationpromotingtubes,afterstandingfor10minutesinlowtemperature,then3000r/mincentrifugal15minutes,serumwasextractedfromtesttube,thenwasrefrigeratedin-80℃.Thecontrolgroupwerecollectedvenousbloodatthecorrespondingtime,se
2、rumwasobtainedbycentrifugation.WeusedtheELISAkittodetectofFGF21.5.Statisticanalysis:Continuousvariableswereexpressedasmean±standarderrorandcategoricalvariablesbythechi-squaretest.Forallanalysis,apvaluelessthan0.05wasconsideredsignificant,usingastatisticalprogram(spssversion21.0).ResultsAllo
3、fthepatientsdidn’tdieatthetimeofadmission,andthecontentofserumFGF21canaccuratelydetect.SerumFGF21levelofthepatientswithacutemyocardialinfarctionincreasedsignificantly,thendecreased.Atthethirddayafteroperation,thepatientsinthetreatmentgroupthelevelofFGF21waslowerthanthecontrolgroup.Inallrece
4、ivedemergencyoperation,accordingtoTIMIflowgrade,thpatientsweredividedintono-reflow(NR)groupandnormalreflowgroup.SerumFGF21leveloftheformerwasslightlyhigherthanthelatter(P=0.414),after1day,theserumlevelsofFGF21intheformerweresignificantlyhigherthanthelatter.Thepatientswithnromalflowweredivid
5、edintocombinedwithdiabetesandnodiabetesgroup.TheresultsshowedthatserumFGF21levelofpatientswithdiabetesisalwaysslightlyhigherthanthosewithoutdiabetes,buttherewasnostatisticalsignificantdifference(P>0.05).InpatientswithacuteSTEMI,causedbyanteriordescendingbranch,betweenthelevelofserumFGF21atf
6、irstdayafteroperationandleftventricularejectionfractionatfirstdayafteroperationshowsasignificantlynegativecorrelation(R=-0.541,P<0.001);meanwhilebetweenthelevelofserumFGF21atthirddayafteroperationandleftventricularejectionfractionatfirstdayafteroperationshowsasignificantlynegativecorrelatio
7、n(R=0.657，P=0.005).At1thdaysand3thdaysafterPCI,betweenthelevelofFGF21inserumandBNPshowedasignificantpositivecorrelation(R=0.795,P<0.001;R=0.657,P=0.005).ConclusionsTheserumlevelofFGF21inpatientswithAMIincreasedsignificantlyandthen万方数据decreased,whichdoesn
