冠心病患者血浆脂联素与血管内皮功能指标内皮素-1、no、vwf的相关性-研究

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1、英文摘要AssociationofPlasmaAdiponectinandET-1，NOandvWFinPatientswithCoronaryHeartDiseaseABSTRACTObjective：Adiponectin(APN)isanewlydetectedadipose-specificplasmaproteinandabundantinbloodstreamofnormalpeople．Recentinvestigationshaveindicatedthatadiponectinrelatedtoseveralfacetso

2、ftheatherosclerosisbysuppressingexpressionofendothelialcelladherencefactors，proliferationofsmoothmusclecell，differentiationofmacrophagestofoamcells，terminationinflammatoryreaction，resistingatherosclerosis，protectingendothelialcell，andSOon．Inaddition，Furtherinvestigationswi

3、llimproverecognitiononoccurrenceanddevelopmentofatherosclerosisandprovideanewpathwaypreventatherosclerosis．Inpresent，investigationshaveindicatedthattheplasmaadiponectinlevelsinpatientswithcoronaryheartdiseasewerelowercomparedwiththosewithhealthysubjects．Buttherelationshipb

4、etweenadiponectinandendothelialmarkersofplasmaendothelin一1(ET-1)，Nitricoxide(NO)，vonWillebrandfactor(VwF)hasbeenresearchedless．Inthisexperiment，theplasmalevelsofadiponectin，ET-1，NOandvVi／Finpatientswithcoronaryheartdiseasewereresearched．Todetecttherelationshipbetweenadipon

5、ectinandtheendothelialmarkersofplasmaET-1，NO，vWF4荚文摘要Methods：60patientSwithcoronaryheartdisease(CHD)，whocamefromtheinpatientsof2thhospitalaffiliatedwiththeHEBEIMedicalUniversity(47malesand13females)，withaverageageof52．4±8．0years．ThepatientswithCHDweredividedintotwogroups：t

6、hestableanginapectoris(SAP)group(29malesand6females)withaverageageof52．8+7．2yearsandtheacutecoronarysyndrome(ACS)group(18malesand7females)withaverageageof51．8±9．1years．ThediagnosticcriteriaofliD，SAPandACSwerebasedon“internalmedicineofthesixthedition”andcoronaryangiography．

7、Another28healthypeoplewereincontrolgroup(20malesand8females)，withaverageageof49．5+7．6years．TheywereruledoutCI-IDthroughelectrocardiogramexercisetestorcoronaryangiography．Allsubjectsnotonlyhadexcludedbodymassindex(BMI)一>25kg／mzand<18．5kg／m2,butalsohadnootherdiseasessuchasCe

8、rebrovasculardisease，MainArterydisease，LiverandKidneydisease，Metabolicdisease(Diabetes，Hy