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1、andascitesformedgradually;loseoffur,anddifferenthaircolor,partoftheratsappearpatchyhairremoval,skinulcersandnecrosis.Comparedwiththemodelgroup,treatmentgroupshavethesimilarsymptomslater,andlighter.②Ratscardiacfunction:Comparedwiththenormalcontrolgroup,modelgroupratsaverageLVSPand±dp/
2、dtmaxdecreasesignificantly(P<0.01),whiletheaverageLVDPincreasedsignificantly(P<0.01).Comparedwiththemodelgroup,LVSP,LVDP,±dp/dtmaxofFuxinTanglowdosegroupshownosignificantdifferences(P>0.05);whileFuxinTanghighdosegroupshowsignificantdifferences(P<0.01).③RatsserumTNF-alevel:Comparedwit
3、hthenormalcontrolgroup,modelgroupratsserumTNF-alevelareincreasedsignificantly(P<0.01).Comparedwiththemodelgroup,theTNF-alevelofFuxinTanglowdosegroupdecreased(P<0.05);theTNF-alevelofFuxinTanghighdosegroup,andcaptoprilgrouparesignificantlydecreased(P<0.01).④Pathologicalchangesofmyocard
4、iuminrats:Normalcontrolgrouprats’myocardialcellmorphology,cytoplasmic,interstitialandhorizontal(vertical)linesarenormal.Comparedwiththemodelgroup,themyocardialtissueofratsareseverelydamaged,thenucleiarrangesirregularly,partofthemyocardialnucleararepyknosis,andfragmentation,musclefibe
5、rsarederangement,andinterstitialedemavaries,changelikecardiomyopathypresenting.Comparedwiththemodelgroup,thetreatmentsgroupratmyocardialtissuemorphologyimproveofdifferentdegrees.⑤TheexpressionofRatmyocardialproteinCaspase-8andBcl-2:Comparedwiththenormalcontrolgroup,theexpressionofmod
6、elgroupratsmyocardialproteinCaspase-8aresignificantlyelevated(P<0.01),theexpressionofproteinBcl-2aresignificantlydecreased(P<0.01).Comparedwiththemodelgroup,theexpressionofFuxinTanglowdosegroupratsmyocardialproteinCaspase-8,Bcl-2hasnoobviousstatisticaldifference(P>0.05);FuxinTanghigh
7、dosegroupratsmyocardialproteinCaspase-8expressionaresignificantlydecreased(P<0.01),proteinBcl-2expressionincreasesignificantly(P<0.01);captoprilgroupratsexpressionofmyocardialproteinCaspase-8decreasedsignificantly(P<0.01),proteinBcl-2expressionincreasesignificantly(P<0.05).2.Clinical
8、researchresu
