咳嗽变异性哮喘患儿皮肤点刺和血清总ige检测及诊断意义

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1、皮肤点刺和血清总IgE检测对儿童咳嗽变异性哮喘患儿皮肤点刺和血清总IgE检测的及诊断意义汪万军陈建平桂芹王刚何念海（400038重庆，第三军医大学西南医院儿科）【摘要】目的检测儿童咳嗽变异性哮喘患儿探讨皮肤点刺情况和血清IgE水平，探讨其在儿童咳嗽变异性哮喘中的诊断意义。方法分别测定并比较125例咳嗽变异性哮喘（CoughVariantAsthmaCVA）患儿，128例支气管哮喘患儿及同期我院体检的126例正常健康儿童血清IgE水平和皮肤点刺结果。结果①CVA组与哮喘组血清总IgE水平比较无统计学意义（P

2、=0.802），CVA组、哮喘组患儿血清总IgE水平显著高于正常健康组（P<0.01）。②CVA组与哮喘组摄入性变应原、吸入性变应原、总变应原阳性率比较均无统计学意义（P>0.05）；CVA组、哮喘组与健康组摄入性、吸入性、总变应原阳性率比较均有统计学意义（P<0.01）；CVA组、哮喘组、健康组内摄入性、吸入性变应原阳性率比较均有统计学意义（P<0.05）？没有区别？。③125例CVA患儿皮肤点刺试验阳性率为65.6%。吸入变应原总阳性率52.8%,吸入变应原中以粉尘螨和屋尘螨阳性率居高,分别为46.4

3、%和43.2%；摄入变应原总阳性率28.8%,摄入变应原主要为海蟹33.6%,鸡蛋清22.4%。皮肤点刺结果强阳性以粉尘螨和屋尘螨为主,分别为24.0%和21.6%。结论皮肤点刺试验和血清总IgE在CVA儿童中有较高的阳性检出率,对CVA的诊断有重要意义。【关键词】咳嗽变异性哮喘；儿童；皮肤点刺；总IgE【中图分类号】R725【文献标志码】AAnalyzingclinicalsignificanceofskinprinktestandtotalIgEInseruminchildrenwithcoughva

4、riantasthmaWangWanjunChenJianpingGuiQinWangGangHeNianhai请补充英文单位名称【Abstract】ObjectiveToexploretheroleofskinpricktest(SPT)andserumtotalimmunoglobulinE(TIgE),inthediagnosisofchildrenwithCoughVariantAsthma(CVA).MethodsTIgEandSPTweredetectedin125patientswithCV

5、A,128withbronchialasthmaand126ofhealthychildrenreceivedmedicalexaminationinourhospital(controls).Results同中文修改①TheconcentrationofTIgEshowednodifferencesbetweenthepatientswithCVAandbronchialasthma(P=0.802).TheTIgElevelsinbothgroupsofCVAandbronchialasthmawer

6、ehigherascomparedwiththecontrols(P<0.01).②Thepositiverateofinhaled,foodandtotalallergensofSPTshowednodifferencesbetweenthepatientswithCVAandbronchialasthma(P>0.05);Thepositiverateofinhaled,foodandtotalallergensofSPTshowedsignificantlydifferencesbetweenthe

7、patientsofCVAandbronchialasthmawithcontrols(P<0.01);ThepositiverateofinhaledandfoodallergensofSPTshowedsignificantlydifferencesamongCVA,bronchialasthmaandcontrol(P<0.05);③SPTshowedpositivein82cases(65.6%).Thepositiveratesofinhaledandfoodallergenswere52.8%

8、and28.8%,respectively.dermatophagoidesfarinaeanddermatophagoidespteronyssinusweretwocommoninhaledallergens(46.4%and43.2%respectively).Crabwasthemostcommonfoodallergen(33.6%),followedbyeggalbumen(22.4%).Thestrongestr