crp1059g-c基因多态性与冠心病相关性的临床荟萃分析

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1、医学论文-CRP+1059G>C基因多态性与冠心病相矢性的临床荟萃分析作者：戴振宇徐力辛田克钧符月琴梅喜平张萍【摘要】目的评价CRP(C反应蛋白)+1059G乂基因多态性与冠状动脉粥样硬化性心脏病相矢性。方法全面检索矢于CRP多态性与冠心病矢系的原始研究，将符合入选标准的研究纳入。采用Revman4.2统计软件包及statalO.0统计软件包进行统计,计算合并的效应指标基因多态性以OR及95%可信区问为效应指标。结果入选的8个冠心病与CRP多态性矢系的原始研究采用Mantel・Hdcnszcl固定效应模型合并的(GC+CC)基因型/GG基因型OR值为1.1895%

2、CI为1.01〜1.39，P<0.05。按地域分层分析固定效应模型中国人群OR为0.85，95%CI为0.64〜1.14，P>0.05欧美人群随机效应模型其OR为1.35，95%CI为1.11〜1.63，P<0.05。结论CRP+1059G>C基因多态性与欧美人群冠心病发病相另，但可能与中国人群冠心病发病无尖，C等位基因携带者患冠心病的危险性有增高趋势。【矢键词】CRP冠状动脉粥样硬化性心脏病基因多态性相矢性荟萃分析[Abstract]ObjectiveToinvestigatethecorrelationbetweenthepolymorphismofC-rea

3、ctiveproteingene+1059G/Candtheriskofcoronaryheartdisease(CHD)withMetaanalysismethod.MethodsDatabaseswerecomprehensivelysearched?togetherwithreferencesretracingmethod?foralltherelatedstudiesonthecorrclationbetweenC・reactiveproteingene+1059G/CpolymorphismandtheriskforCHD.Al1therelatedst

4、udieswerefurtherstrictlyselectedaccordingtotheinclusioneriteria・C・reactiveproteingeneGCandCCgenotypevsGGgenotypeOR(oddsratio)andits95紀【(confidenceinterval)wereanalyzedasanoutcomemeasurement.ThestatisticalpackagesStatal0.0andReman4.2wereappliedforinvestigatingheterogeneityamongindividu

5、alstudiesandsummarizingoveral1effectsacrossstudiesbypropermathematicalmodel・Results9originalstudieswereenteredthefinaldatacombination.WiththeMante1・Haenszelfixeffectmathematicalmodel，thepooledoddsratiofor(GC+CC)/GGinCHDgroupagainstcontrolgroupwas1.18，95%C1(1.01〜1.39)'PC0.05-Hierarchie

6、sanalysisaccordingtotheregionaldistributionshowedtheORoftheChinesepopulationis0.85,95%CI0.64〜1.14,P〉0.05,usingtherandomeffectsmodelanalysistheEuropeanandtheUnitedStatespopulation,OR1.35,95%CI1.11〜1.63，P<0.05・ConclusionThepolymorphismofC・reactiveproteingcnc+1059G/Cisassociatedwithcoron

7、aryheartdiseaseinEuropeanandtheUnitedStatespopulation，butthereisnoassociationbetweenthepolymorphismofC-reactiveproteingene+1059G/CandcoronaryheartdiseaseinChinesepopulation,peoplewhocarrytheCallele(GCandCCgenotypes)haveahigherrisktobesubjecttocoronaryheartdisease•[Keywords]C-reactivep

8、rotei