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1、健康成年人海马磁共振波谱和扩散加权成像探究【摘要】目的：利用氢质子磁共振频谱和扩散加权成像，分析健康青年、中年两个年龄组两侧海马的脑代谢物浓度及表观扩散系数(ADC值)的变化，旨在为各种与海马相关疾病的早期诊断和病情评估提供依据。方法：对40名健康青年、中年两组志愿者双侧海马行磁共振波谱(MRS)及扩散加权成像(DWI)检查，计算双侧海马N-乙酰天门冬氨酸/(肌酸+胆碱)NAA/(Cr+Cho)、NAA/Cr、NAA/Cho和Cho/Cr值及表观弥散系数(ADC)值。结果：健康成年人左、右两侧海马的脑代谢物浓度NAA/(Cr+Cho)、NAA/Cr、
2、NAA/Cho和Cho/Cr比值及表观弥散系数(ADC)值比较差异均无统计学意义(P>0.05)。健康青年组、与健康中年组海马的脑代谢物浓度NAA/(Cr+Cho)、NAA/Cr、NAA/Cho和Cho/Cr比值及表观弥散系数(ADC)值比较差异均无统计学意义(P>0.05)o结论：以氢质子磁共振频谱和扩散加权成像测定的NAA/(Cr+Cho)、NAA/Cr、NAA/Cho和Cho/Cr值及ADC值为标准，为各种与海马相关疾病的早期诊断和病情评估提供依据。【关键词】健康成年人；氢质子磁共振频谱；扩散加权成像；海马HealthyAdultHippoca
3、mpalMagneticResonanceSpectroscopyandDiffusion-weightedImagingStudies/HAOJing-jun,ZHUANGWei-xiong,WENHai-zhong,etal.//MedicalInnovationofChina,2014,11(12)：072-074[Abstract】Objective：Toanalyzehealthyyoung,middle-agedbrainmetaboliteconcentrationsonbothsidesofthehippocampusinbothag
4、egroupsandapparentdiffusioncoefficient(ADCvalue)changes,aimatallspeciesandprovidingthebasisforearlydiagnosisandassessmentofdiseasehippocampus-relateddiseases.Method:Checkedtwobilateralhippocampalmagneticresonancespectroscopy(MRS)anddiffusion-weightedimaging(DWI)of20healthyyoung
5、volunteersand20healthymiddle-agedvolunteers,calculatedbilateralhippocampalN-acetylaspartate/(creatine+gallalkali)NAA/(Cr+Cho),NAA/Cr,NAA/ChoandCho/Crvaluesandapparentdiffusioncoefficient(ADC)values.Result：HealthyadultsleftandrightsidesofNAA/(Cr+Cho),NAA/Cr,NAA/Cho,Cho/CrandADCv
6、aluehadnosignificantdifferenee(P>0.05)・Therehadnosignificantdifferenceofbetweenhealthymiddle-agedgroupandthehealthyyounggroupinNAA/(Cr+Cho),NAA/Cr,NAA/Cho,Cho/CrandADCvalue(P>0.05).Conclusion：Theprotonmagneticresonancespectrumanddiffusion-weightedimagingmeasureNAA/(Cr+Cho),NAA/
7、Cr,NAA/ChoandCho/CrvaluesandADCvaluecriteriafortheearlydiagnosisofvariousdiseasesassocia.tedwiththehippocampusandprovidethebasisforassessingthecondition.[Keywords】HealthyaduIts；Hydrogenprotonmagneticresonancespectrum；Diffusion-weightedimaging；HippocampusFirst—author?saddress：Th
8、ePeople，sHospitalofYunfuCity,Yunfu527300,Chinadoi：10.3
