horizonal gene transfer in the evolution of pathogens0521862973

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1、P1:JZPmanualcuus1179780521862974TopMargin:0.90625inGutterMargin:0.79034inMay23,200817:36ThispageintentionallyleftblankiiP1:JZPmanualcuus1179780521862974TopMargin:0.90625inGutterMargin:0.79034inMay23,200817:36HorizontalGeneTransferintheEvolutionofPathogenesisHorizontalgenetransferis

2、amajordrivingforceintheevolutionofmanybacterialpathogens.Thedevelopmentofhigh-throughputsequencingtoolsandmoresophisticatedgenomicandproteomictechniquesinrecentyearshasresultedinabetterunderstandingofthisphenomenon.Writtenbylead-ingexpertsinthefield,thiseditedvolumeisaimedatgraduate

3、studentsandresearchersandprovidesanoverviewofcurrentknowledgerelatingtotheevolutionofmicrobialpathogenicity.Thisvolumeprovidesanoverviewofthemechanismsandbiologicalconsequencesofthegenomerearrangementsresultingfromhorizontalgenetransfer,inbothprokaryotesandeukaryotes,aswellasovervi

4、ewsofthekeymobilegeneticelementsinvolved.Subse-quentchaptersfocusonparadigmsfortheevolutionofimportantbacte-rialpathogens,includingSalmonellaenterica,Streptococcuspneumoniae,andStaphylococcusaureus.Theinfluenceofsocioeconomicparametersinthedis-seminationoftransferableelements,suchas

5、antibiotic-resistantgenesinbacteria,isalsodiscussed.MichaelHenseliscurrentlyProfessorofMicrobiologyandImmunologyattheUniversityofErlangeninGermany.HerbertSchmidtiscurrentlyProfessorofFoodMicrobiologyattheUniver-sityofHohenheiminGermany.iP1:JZPmanualcuus1179780521862974TopMargin:0.9

6、0625inGutterMargin:0.79034inMay23,200817:36iiP1:JZPmanualcuus1179780521862974TopMargin:0.90625inGutterMargin:0.79034inMay23,200817:36Overthepastdecade,therapiddevelopmentofanarrayoftechniquesinthefieldsofcellularandmolecularbiologyhastransformedwholeareasofresearchacrossthebiologica

7、lsciences.Microbiologyhasperhapsbeeninflu-encedmostofall.Ourunderstandingofmicrobialdiversityandevolutionarybiologyandofhowpathogenicbacteriaandvirusesinteractwiththeiranimalandplanthostsatthemolecularlevel,forexample,hasbeenrevolutionized.Perhapsthemostexcitingrecentadvanceinmicrob

8、iologyisthefusionofclassic