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1、山萇蓉碱对创伤性肺损伤防治作用的实验研究ScopolamineisanexperimentalstudyoftheeffectsoftraumaticlunginjuryUpdatedate:2010-07-03liangjihezhuyunxili【abstract】objectivetodiscussthepreventionandpossiblemechanismofscopolamine(654-2)ontraumaticacutelunginjury(ALI).Methodsobserving654-2traumaticALIrabbitplasmaandbronchoal
2、veolarlavagefluid(BALF)oftumornecrosisfactoralpha(TNFalpha)andinterleukin8(IL-8)contentandtheeffectoflightmicroscopeandelectronmicroscopeexaminationoftheorganizationpathologyatthesametime,andinsituhybridizationmethodtodetectlungandotherorganstissueTNFalphaandmRNAexpressionofIL一8.Theresultofthei
3、njurywas654-2,whichcouldmakethetraumaticALIrabbitbloodplasmaandthetnf-alphainBALF,theapparentreductionin订-8,andthereductionoflungtissueinjury・TNFalphamRNAandIL一8mRNAgeneexpressionmainlylocateinthetissueofvisceralM,PMNandvascularendothelialcells(VEC),expressnumberdecreasedsignificantly.Conclusio
4、n654~2candecreasetheplasmaandBALFofthecontentofTNFalpha,IL-8,theTNFalphamRNAandIL-8mRNAgeneexpression,tosomeextent,soastoreduceorpreventtheoccurrenceanddevelopmentoftraumaticALI.【keywords】theexpressionofthenecroticfactorofthetumornecrosisfactor一alphainterleukin-8TheExperimentalStudyofPreventive
5、andTherapeuticEffectsofAnisodamineonTraumaticAcuteLungInjury,LIQi,ZHUyim-xi,LIQi,etalDept・OfCardiothoracicSurgery,XijingHospital,FourthMilitaryMedicalUniversity,xi'an710032[Abstract]AimToinvestigatethepreventiveandtherapeuticeffectsofanisodamine(654-2)ontraumaticacutelunginjuryandtheirmechanism
6、・Methods654-2wasusedintheprophylaxisandtreatmentoftherabbitswithtraumaticacutelunginjury.Thechangesofthecontentsoftumornecrosisfactor-a(TNF-ci)andinterleukin-8(IL~8)inplasmaandbronchoalveolarlavagefluid(BALF)wereobserved・Mea’nwh订e,thepathologicchangeswereexaminedwithopticalmicroscopeandTVmicros
7、coperespectively.InsituhybridizationtestwasusedtodetectthegeneexpressionandcelllocalizationofTNF-ciandIL-8・Results654-2coulddecreasethecontentsofTNF-ciandIL~8inplasmaandBALFandalleviatethepulmonarytissueinjury.GeneexpressionofTNF-
