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ID:30958772
大小:302.00 KB
页数:6页
时间:2019-01-04
《hif-1α和c-met在喉鳞癌中的表达及其与微血管密度的关系》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、HIF-1α和c-met在喉鳞癌中的表达及其与微血管密度的关系孙旭娄卫华郑州大学第一附属医院郑州450052摘要目的:探讨观察缺氧诱导因子-1α(hypoxia-induciblefactorlalpha,HIF-1α)、肝细胞生长因子受体(hepatocytegrowthfactorreceptor,c-met)在喉鳞状细胞癌发生发展和淋巴转移中的作用。方法:采用免疫组化SP法,检测HIF-1α和c-met在喉鳞状细胞癌不同分化类型中的表达(58例),并测定微血管密度(microvesseldensity,MVD),观察HIF-1α、c-met和MVD之间的
2、联系。结果:HIF-1α、c-met在喉癌中阳性区平均积分光密度(theaverageintegratedopticaldensity,AIOD)及MVD随分化程度降低而增高(P<0.05)。颈淋巴结转移组AIOD及MVD明显高于未转移组(P<0.05)。HIF-1α与c-met在喉癌中的表达呈明显正相关(P<0.001)。HIF-1α、c-met与MVD也呈明显正相关(P<0.001)。结论:HIF-1α、c-met在喉鳞状细胞癌的发生、发展、淋巴结转移中起重要作用,且两者存在有协同作用。HIF-1α、c-met可能作为治疗喉鳞癌的潜在靶点。关键词:喉鳞癌;
3、缺氧诱导因子-1α;肝细胞生长因子受体;微血管密度中图分类号:R767TheSignificanceandRelationshipbetweenHIF-1α,C-metandMicrovesselDensityExpressioninLaryngealCarcinomaXuSunWeihuaLouTheFirstAffiliatedHospitalofZhengzhouUniversityZhengzhou450052通信作者:娄卫华教授。郑州大学一附院联系电话13676991909E-mail:sun120xu@yahoo.cnABSTRACTObjecti
4、ve:ToevaluatetheroleofHIF-1αandC-metintumorigenesisandmatastasisoflaryngealsquamouscellcarcinoma.Methods:Immunohistochemicaltechnique(streptavidinperoxidasemethod)wasappliedtoexaminingexpressionofHIF-1α,C-metandCD34inthreetypesofdifferentiationoflaryngealsquamouscellcarcinoma(58tiss
5、uesamples).InvestigatetherelationshipbetweenHIF-1α,C-metandCD34.Results:Theaverageintegratedopticaldensity(AIOD)ofpositiveareaandMVDinpoorlydifferentiatedlaryngealcarcinomaweresignificantlyhigherthanthatinwelldifferentiatedlaryngealcarcinomaandmoderatelydifferentiatedlaryngealcarcin
6、oma(P<0.05),TheAIODofpositiveareaandMVDinmoderatelydifferentiatedlaryngealcarcinomaweresignificantlyhigherthanthatinwelldifferentiatedlaryngealcarcinoma(P<0.05).TheAIODofpositiveareaandMVDingroupwithlymphnodemetastasisweresignificantlyhigherthanthatingroupwithoutlymphnodemetastasis.
7、TheexpressionofHIF-1αandc-metwerepositivelycorrelated(P<0.001).TheexpressionofHIF-1αandc-metpositivelycorrelatedwithMVDexpression(P<0.001).Conclusion:TheexpressionofHIF-1αandc-metplayedanimportantroleinthetumorigenesisandmatastasisoflaryngealsquamouscellcarcinoma.TheexpressionofHIF-
8、1αwascorrelatedwith
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