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1、从本学科出发，应着重选对国民经济具有一定实用价值和理论意义的课题。课题具有先进性，便于研究生提出新见解，特别是博士生必须有创新性的成果XRCC2基因多态性与非小细胞肺癌易感性的关系作者：王瑞，曾辉，李琰，王娜，张健慧，张金文，王伟，刘俊峰【关键词】非小细胞肺癌；XRCC,2基因；易感性；遗传多态性 AssociationbetweengenepolymorphismofXRCCandsusceptibilityofnonsmallcelllungcancers 1DepartmentofThoracicSurg
2、ery,FourthAffiliatedHospital,HebEiMedicalUniversity,LaboratoryofMolecularBiology,HebEICancerInstitute,Shijiazhuang,China,NationalCenterforAIDSControlandPrevention,ChineseCenterforDiseaseControlandPrevention,Beijing,China,OperationRoom,ThoracicHospitalofHebeiPr
3、ovince,Shijiazhuang,China,DepartmentofSurgery,ChenganCountyHospitalofHebeiProvince,Handan,China 【Abstract】AIM:ToobservetheassociationbetweentheriskofnonsmallcelllungcancersandpolymorphismandgenefrequencyofXRCCC41657TandG4234CinnorthChineseHanpopulation.METHOD
4、S:Thesinglenucleotidepolymorphisms(SNPs)oftheC41657T课题份量和难易程度要恰当，博士生能在二年内作出结果，硕士生能在一年内作出结果，特别是对实验条件等要有恰当的估计。从本学科出发，应着重选对国民经济具有一定实用价值和理论意义的课题。课题具有先进性，便于研究生提出新见解，特别是博士生必须有创新性的成果andG4234CintheXRCCgeneweregenotypedbyPCRRFLPanalysisin2nonsmallcelllungcancerpatients
5、and00healthycontrols.RESULTS:TherewasXRCCgeneC41657TandG4234CpolymorphisminnorthChineseHanpopulation.ThegenotypeandallelotypedistributionsoftheXRCCC41657TandG4234CSNPsinthenonsmallcelllungcancerpatientswerenotsignificantlydifferentfromthoseofthecontrols(allP>)
6、.WhenthetwoXRCCSNPswerecombined,thehaplotypedistributioninthenonsmallcelllungcancerpatientswasalsonotsignificantlydifferentfromthatofthecontrols(P>).Butstratificationanalysisaccordingtohistologicaltypesandsmokingstatusshowedthat,comparedwithC/Cgenotype,thecomb
7、inationofC/TandT/TgenotypesofXRCCC41657Tincreasedtheriskofdevelopingnonsmallcelllungcancer(OR:,5%CI:)andthatofadenosquamouscarcinoma(OR:.45,5%CI=)innonsmokers.NoassociationwasobservedbetweenXRCCG4234Candthetypeofnonsmallcelllungcancers,andalsotherewasnoevidenc
8、efortheinteractionbetweenXRCCG4234Candsmokingstatus.CONCLUSION:XRCCgeneC41657Tallelemaybeasusceptibilityfactorforthedevelopmentof课题份量和难易程度要恰当，博士生能在二年内作出结果，硕士生能在一年内作出结果，特别是对实验条件等要有恰
