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时间:2018-12-07
《奥扎格雷联合低分子肝素钙治疗脑血栓的临床疗效观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、奥扎格雷联合低分子肝素钙治疗脑血栓的临床疗效观卢鹏飞岳阳市岳化医院内一科湖南岳阳414014【摘要】目的:探讨奥扎格雷联合低分子肝素钙治疗脑血栓的临床疗效。方法:选取68例脑血栓作为研究对象,两组患者均在常规治疗的基础上,对照组采取奥扎格雷治疗,观察组采取奥扎格雷联合低分子肝素钙治疗;对比两组患者治疗前后血浆血管性假血友病因子抗原(vWF:Ag)、抗凝血酶(AT)、D-二聚体(D-Dimer)水平改善程度,根据神经功能缺损程度评分标准,综合评价患者的临床疗效。结果:治疗前,两组患者血浆vWF:Ag、AT、D-Dimer水平差异无统计学意义(P>0.05);治疗后,观察组患者的
2、血浆vWF:Ag、D-Dimer水平低于对照组,AT水平高于对照组,经T检验,差异具有统计学意义(P<0.05);观察组临床总显效率为85.29%,大于对照组的52.94%,经χ2检验,差异A有统计学意义(P<0.05)。结论:奥扎格雷联合低分子肝素钙治疗脑血栓的临床疗效显著,可明显消除患者的凝血状态,对于恢复缺损的神经功能,改善预后其有积极作用。【关键词】脑血栓;奥扎格雷;低分子肝素钙ClinicalefficacyozagrellowmolecularweightheparintherapyofcerebralthrombosisLuPengfeiYueyangC
3、ity,YueyangHospitalMedicineHunanYueyang414014[Abstract]Objective:ToevaluatetheclinicalefficacyOzagrellowmolecularweightheparintreatmentofcerebralthrombosis.Methods:68casesofthrombosisforthestudy,twogroupsofpatientswereonconventionaltherapy,thecontrolgrouptakingozagreltreatment,observationgr
4、ouptakeozagrellowmolecularweightheparintherapy;twogroupsofpatientsbeforeandaftercomparisonofplasmavonWillebrandfactorantigen(vWF:Ag),antithrombin(AT),D-dimer(D-dimer)levelsthedegreeofimprovement,accordingtothedegreeofneurologicaldeficitscore,comprehensiveevaluationofclinicalefficacyinpatien
5、tswith.Results:Beforetreatment,thetwogroupsofplasmavWF:Ag,AT,D-Dimerlevelwasnosignificantdifference(P>0.05);Aftertreatment,patientsobservedinplasmavWF:Ag,D-Dimerlevelsthanthecontrolgroup,ATlevelwashigherbyTtest,thedifferencewasstatisticallysignificant(P<0.05);clinicalobservationgroupt
6、otaleffectiveratewas85.29%,52.94%higherthanthecontrolgroup,theχ2test,thedifferencewasstatisticallysignificant(P<0.05).Conclusion:Theclinicalefficacyozagrellowmolecularweightheparintherapythrombosissignificantly,cansignificantlyeliminatethecoagulationstatusofthepatient,fortherestorati
7、onofneurologicaldefectsandimproveprognosishaveapositiveeffect.Keywords:cerebralthrombosis;ozagrel;lowmolecularweightheparin脑血栓作为常见的缺血性脑血管疾病,以脑动脉血栓性堵塞,导致血液灌注区域组织缺血、缺氧及坏死,引起神经功能缺损综合征[1]。由于脑血栓的发病率、致残率、死亡率均较高,对于脑血栓的防治水平,对于减小脑血栓危害具有重要作用。在临床上,脑血栓与动脉粥样硬化、血流动力学异
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