小儿麻醉前清醒、镇静中右美托咪啶经鼻给药的临床效果

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1、小儿麻醉前清醒、镇静中右美托咪噪经鼻给药的临床效果（1.庆元县人民医院浙江庆元323800；2.丽水市中心医院浙江丽水323000）【摘要】目的：探讨术前经鼻滴注中右美托咪唳在小儿麻醉前镇静中的应用效果。方法：选择小儿外科行手术的患儿126例，用随机数字表法将患儿分为M组（咪卩坐安定组）与D组（右美托咪噪组）每组63例。M组经鼻滴注咪卩坐安定0.2mg/kg,D组经鼻滴注右美托咪®2.0µg/kgo分别经鼻给药前（门）、给药后5分钟仃2）、给药后15分钟（T3）、入手术室麻醉诱导前（T4）,对患儿进行镇静评分、行为评分登记，记录相关生命体征。结果：M组患儿入睡时间短

2、于D组，T3、T4时M组患儿的镇静评分与行为评分均低于D组，M组患儿的氧饱和度变化与D组比较差异有统计学意义P<0.05；T4时D组患儿的HR下降与M组比较差异有统计学意义P<0.05。结论:经鼻给予右美托咪噪2.0µg/kg能有效的改善患儿术前的焦虑状态，麻醉起效后不影响患儿的呼吸，能安静地与父母分离，麻醉诱导时患儿合作，提高了麻醉诱导期患儿的舒适性。【关键词】小儿；右美托咪噪；经鼻给药；清醒；镇静【中图分类号】R739【文献标识码】B【文章编号】1004-6194（2015）02-0175-02Clinicaleffectsofintranasala

3、dministrationofdexmedetomidineonchildrenwithclearconsciousunderpreanesthesiasedationFanXiaominglWangChuanguang2GaoLijuan2ShenShangronglCaiHuanyoulWuWei2ZhangHeng2（1QingyuanPeople’sHospital,ZhejiangQingyuan,323800;2LishuiCenterHospital,ZhejiangLishui,323000）【Abstract]Objective:Toinvesti

4、gatetheeffectsofpreoperativeintranasaladministrationofdexmedetomidineforchildrenunderpreanesthesiasedation.Methods:126casesofchildrenwithpediatricoperationwererandomizedintogroupM(midazolamgroup,n二63)andgroupD(dexmedetomidinegroup,n二63).GroupMwasgivenintranasaladministrationofmidazolam(0.2mg

5、/kg)whilegroupDwasgivenintranasaladministrationofdexmedetomidine(2.0µg/kg).Sedationscoresandbehaviorscoresofthechildrenwererecordedbeforeadministration(Tl),5min(T2)and15min(T3)afteradministrationandbeforeanesthesiainduction(T4),andthecorrespondingvitalsignswererecorded.Results:Children

6、ingroupMhadshortertimetofallasleepthangroupD.TheirsedationscoresandbehaviorscoresatT3andT4werelowerthangroupD.TherewerestatisticallysignificantdifferencesbetweengroupMandgroupDinoxygensaturationchange(P<0.05);andinHRdecreaseatT4(P<0.05).Conclusion:lntranasaladministrationofdexmedetomid

7、ine(2.0µg/kg)caneffectivelyimprovethepreoperativeanxietyofchildren,butdoesnotaffectthechildren’sbreathafteranesthesia.Sothechildrencanbeseparatedfromtheirparentsquietly,andbecooperatedduringinductionofanesthesia,soastoimprovethechildren