来氟米特联合雷公藤多苷治疗难治性肾病综合征疗效观察

《来氟米特联合雷公藤多苷治疗难治性肾病综合征疗效观察》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、寺联緒公瞬苛台性合彳10?535见察2018-03-2910:29:58中国现代医生2018年6期郭勇［摘要］戸的探讨來氟米特联合雷公藤多背治疗难治性肾病综合征的疗效。方法将60例难治性肾病综合征患者采取随机数字衣法分为观察组和对照组，每组各30例，对照组予环磷酰胺联合泼尼松治疗，观察组予來氟米特联合雷公藤多齐治疗，治疗后对两组的临床总缓解率及肾功能各项指标治疗前后的变化请况进行比较分析。结果观察组患者治疗后的总缓解率达90.0%,明显高于对照组,两组比较差异有统计学意义(PvO.05)。治疗后，两组患者

2、的肾功能各项指标较治疗前明显改善，差并均有统计学意义(PvO.05)；治疗后观察组患者的尿蛋白、尿索氮、血肌酉干明显降低，白蛋白明显升高，且较对照组改善更显著(PvO.05)。结论来氟米特联合雷公藤多昔治疗难治性肾病综合征能有效提高临床疗效，改善肾功能，值得临床广泛推广和应用。［关键词］难治性肾病综合征；来氟米特；雷公藤多昔；肾功能［中图分类号］R692.3［文献标识码］B［文章1673-9701(2018)06-0105-02［Abstract］ObjectiveToinvestigatetheeffi

3、cacyofleflunomidecombinedwithtripterygiumglycosidesinthetreatmentofrefractorynephroticsyndrome・MethodsSixtypatientswithrefractorynephroticsyndromewererandomlydividedintoobservationgroupandcontrolgroup,with30casesineachgroup.Thecontrolgroupwasgivencyclopho

4、sphamidecombinedwithprednisone,andtheobservationgroupwasgivenleflunomidecombinedwithtripterygiumglycosidestreatment.Theclinicaltotalremissionrateafterthetreatmentandthechangesofvariousindicatorsofrenalfunctionbeforeandaftertreatmentwerecomparedandanalyzed

5、・ResultsAftertreatment,thetotalremissionrateoftheobservationgroupwas90.0%,whichwassignificantlyhigherthanthatofthecontrolgroup.Therewassignificantdiffereneebetweenthetwogroups(P<0.05)・Theindexesofrenalfunctioninbothgroupsaftertreatmentweresignificantlyimp

6、rovedcomparedwiththosebeforetreatment,andthediffereneewassignificant(P<0.05)・Aftertreatment,theurinaryprotein,ureanitrogenandserumcreatinineintheobservationgroupweresignificantlydecreasedandthealbuminincreasedsignificantly,andtheimprovementintheobservatio

7、ngroupwasmoresignificantthanthatofthecontrolgroup(P<0.05)・ConclusionLeflunomidecombinedwithtripterygiumglycosidesinthetreatmentofrefractorynephroticsyndromecaneffectivelyimprovetheclinicalefficacyandimproverenalfunction,whichisworthwidelyclinicalapplicati

8、on.［Keywords］Refractorynephroticsyndrome；Leflunomide；Tripterygiumglycosides；Renalfunction當正规激素疗程治疗肾病综合征患者的疗效不佳或不能停药、反复发作、不能耐受治疗，称Z为难治性肾病综合征(refractorynephroticsyndrome,RNS)［1］0近年来，难治性原发性肾病综合征的免疫抑制治疗成为临床研究的热点。來烦米特(le