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1、动脉介入尿激酶溶栓治疗急性脑血栓形成早期的疗效观察浏阳市集里医院神经内科湖南浏阳410300【摘要】目的:分析动脉介入尿激酶溶栓治疗急性脑血栓形成早期的疗效。方法:选取93例急性脑血栓形成早期患者作为研究对象,其中观察组52例,釆取动脉介入尿激酶溶栓治疗;对照组41例,采取尿激酶静脉溶栓治疗;对比两组患者治疗前及治疗后2h、6h、24h、72h的欧洲卒中量表(ESS)评分及闭塞血管再通效果。结果:两组患者治疗后2h、6h、24h、72h的ESS评分均显著高于治疗前水平(P<0.05),似观察组患者治疗后2h、
2、6h、24h、72h的ESS评分均明显高于对照组,经T检验,差异具有统计学意义(P<0.05);治疗前,两组患者的TT、PT、FIB差异均无统计学意义(P>0.05);观察组闭塞血管完全再通率为59.61%,部分再通率为30.77%,无变化率为9.62%,对照组闭塞血管完全再通率为36.59%,部分再通率为43.90%,无变化率为19.51%;经秩和检验,观察组闭塞血管再通效果显著优于对照组,差异具有统计学意义(P<0.05)。结论:动脉介入尿激酶溶栓治疗急性脑血栓形成早期的疗效优于静脉溶栓治疗,前者可明显缓
3、解神经功能缺损,对于抑制病情进展,改善预后只有重要作用。【关键词】急性脑血栓;尿激酶;溶栓治疗;动脉介入ClinicalobservationoftheearlystageofacutecerebralthrombosistreatedbyinterventionalthrombolysiswithurokinaseYuanLiFengLiuyangshiJilihospitalDepartmentofNeurologyHunanlLiuyang410300[Abstract]Objective:Toanal
4、yzethecurativeeffectoftheearlystageofacutecerebralthrombosistreatedbyinterventionalthrombolysiswithurokinase.Methods:93casesofacutecerebralthrombosispatientsastheresearchobject,theobservationgroupof52cases,takearteryinterventionalthrombolytictherapy;41cases
5、incontrolgroupweretakenintravenousthrombolytictherapywithurokinase;comparedtwogroupsofpatientsbeforeandaftertreatmentof2h,6h,24h,72hoftheEuropeanStrokeScale(ESS)scoreandrecanalizationeffect.Results:twogroupsofpatientsaftertreatmentof2h,6h,24h,72h,ESSscoresw
6、eresignificantlyhigherthanthatbeforetreatment(P<0.05),butthepatientsintheobservationgroupaftertreatmentof2h,6h,24h,72h,ESSscoresweresignificantlyhigherthanthecontrolgroup,byTtest,thedifferencewasstatisticallysignificant(P<O.O5)beforetreatment,two;grou
7、pTT,PTandFIBshowednosignificantdifference(P>0.05);observationgroupofocclusivevascularrecanalizationratewas59.61%,partialrecanalizationratewas30.77%,nochangerateis9.62%,thecontrolgroupofvascularocclusionrecanalizationratewas36.59%,partialrecanalizationrat
8、e43.90%,nochangerateis19.51%;therankandinspection,observationgrouprecanalizationeffectwassignificantlybetterthanthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.05).Conclusion:interventi