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1、MRI及MRS诊断单发急性炎性脑脱髓鞘疾病的应用价值探析杜碧茵(广州市精神病医院510370)【摘要】目的研宄探讨单发急性炎性脑脱髓鞘疾病的影像学特征及MRI、MRS在疾病诊断中的应用价值。方法选取我院近年来收治的单发急性炎性脑脱髓鞘疾病患者9例作为研宄对象,回顾性分析患者的基木临床资料和影像学检查结果,并对其中枢祌经系统的影像学征象进行分析,讨论其临床特征性。结果9例患者通过MRI诊断可见,1例患者病灶位于基底节区域,8例患者位于额顶叶皮层下白质,病灶边缘光滑,形状规则类圆形,结构层次典型,由病灶中心、环壁与水肿区构成,DW
2、I和FUAR、ADC图均为病变中心低信号,周边高信号;T1WI中心低信号,T2WI中心高信号。经增强扫描,病灶呈现出不规则的开环强化,且无显著占位效应。经MRS诊断,所有患者病变中心区域均有Cho峰增加(Cho/Cr增加)与NAA峰降低(NAA/Cr值降低)的表现。除此之外,3例患者有ml峰增加情况,5例患者有Cr峰降低情况。所有患者经相关治疗复查可见病灶体积、IX域缩小,Cho峰降低和NAA峰恢复。结论单发急性炎性脑脱髓鞘疾病的患者经核磁共振检测,能清晰地观察到病灶的位置、数目、形态、信号特点等MRI表现,还可以在MRS诊断
3、中准确显示NAA峰、Cho峰、Cr峰、ml峰的变化情况,帮助医牛.从患者的影像学征象的特征变化中准确诊断并判断疾病的进展。【关键词】单发急性炎性脑脱髓鞘疾病MRIMRS临床应用【中图分类号】R742【文献标识码】A【文章编号】2095-1752(2014)15-0251-02MRIandMRSdiagnosisofsingleacuteinflammatorydemyelinatingdiseaseofthebrainValueAnalysis【Abstract】ObjectiveStudyinvestigatedthecha
4、racteristicsandMRIimagingsingleacuteinflammatorydemyelinatingdiseaseofthebrain,MRSapplicationsindiseasediagnosis.MethodsAdmittedtoourhospitalinrecentyears,singleacuteinflammatorydemyelinatingdiseaseofthebraininpatientswithninecasesforthestudy,thebasicclinicaldataand
5、imagingfindingswereretrospectivelyanalyzedpatientsandanalyzedforsignsofcentralnervoussystemimagingdiscussitsclinicalcharacteristic.ResultsByMRIdiagnosisofbasalganglialesionsinonecase,thewhitematterislocatedeightcases,thelesionedgessmooth,roundshaperules,hierarchytyp
6、ical.DWIandFLIAR,ADCfigurearelowsignallesioncenter,thesurroundinghighsignal;T1WIcenteroflowsignal,T2WIhighsignalcenter.Throughenhancedscanshowedirregularlesionsstrengtheningtheopen-loopandnosignificantmasseffect.AfterMRSdiagnosis,allpatientshadlesionsinthecentralreg
7、ionincreasedChoandNAApeaklowerpeakperformance.Threepatientshadapeakincreaseinml,5patientshadlowerCrpeakcondition.Reviewofallpatientsseenbytherelevanttreatmentlesionvolume,areashrink,ChoandNAApeakreducepeakrecovery.ConclusionPatientswithsingleacuteinflammatorydemyeli
8、natingdiseaseofthebraindetectedbyMRI,thelesioncanbeclearlyobservedinthelocation,number,morphology,signalcharacteristics,suchasMRIperforman