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1、NeuralBasisforVerbProcessinginAlzheimer’sDisease: AnfMRIStudyMurrayGrossman,PhyllisKoenig,ChrisDeVita,GuilaGlosser,PeachieMoore,JimGee,JohnDetre,andDavidAlsopUniversityofPennsylvaniaSchoolofMedicineNeuropsychology2003,Vol.17,No.4,658–674PSY9118018AbstractPatientswithprobableADhavedif
2、ficultyunderstandingverbs.Toinvestigatetheneuralbasisforthisdeficit,theauthorsusedfMRItoexaminepatternsofneuralactivationduringverbprocessingin11ADpatientscomparedwith16healthyseniors.Subjectsjudgedthepleasantnessofverbs,includingMOTIONverbsandCOGNITIONverbs.HealthyseniorsandADpatien
3、tsbothactivatedposterolateraltemporal(後外側聶葉)andinferiorfrontalregionsduringjudgmentsofverbs.(同時活化只是活化的程度不同)TheseactivationswererelativelyreducedandsomewhatchangedintheiranatomicdistributioninADpatientscomparedwithhealthyseniors,particularlyforthesubcategoryofMOTIONverbs,butADpatients
4、showedminimalactivationinassociationwithCOGNITIONverbs.(AD對cognitionverbs的活化較差)ThesefindingsimplythatpoorperformancewithverbsinADisdueinparttoalteredactivationofthelarge-scaleneuralnetworkthatsupportsverbprocessing.IntroductionPatientswithprobableADarethoughttohavedifficultyunderstan
5、dingsinglewords.PatientswithADappeartohavegreaterdifficultywithverbsthanwithnouns.Althoughexceptionalcaseshavebeendescribed,andarecentstudyinvolvingmanyaxialverbsfailedtoconfirmearlierobservations,theverbimpairmentinADhasbeenshownwithseveraldifferenttechniques,includingconfrontationn
6、aming,word–pictureandword–videomatching,andword–definitionmatching.MethodSubjects(受試者)Westudied16healthy,right-handedseniorsand11patientswithmild-to-moderatedementiadiagnosedasprobableAD.Materials(材料)twocategoriesofverbs:MOTIONverbs(e.g.,CRAWL,WRITE)andCOGNITIONverbs(e.g.,BELIEVE,ENJ
7、OY).ImagingDataAcquisitionandStatisticalAnalysisResultsBehavioralObservationsTheseADpatientsalsohadrelativedifficultywithCOGNITIONverbscomparedwiththeirownperformancewithMOTIONverbs.(表一)表一DuringimagingTable3summarizesthecoordinatesofthepeaklociandtheBrodmannareasassociatedwithactivat
8、ioninhealthy
