血清糖基化白蛋白与糖尿病合并肾病的关系分析

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1、水平与C组之间存在显著差异，则说明GA可能与2型糖尿病出现24小时蛋白尿异常有关。2型糖尿病各组血清糖化血红蛋白HbA1c水平即：B组（6.41±0.81）、C组（7.29±1.39）与A组（5.08±0.25）HbA1c水平相比，差异有显著性。经直线相关分析，2型糖尿病24小时尿蛋白定量与糖化血红蛋白呈正相关，相关性达标（r值：0.490，P值＜0.05）。2型糖尿病24小时尿蛋白定量与糖化血清白蛋白GA呈正相关，相关性达标（r值：0.475，P值：＜0.05）。说明2型糖尿病伴有24小时蛋白尿时GA水平明显升高，同时2型糖尿病伴有24小时蛋白尿量与GA和HbA1c均相关，支持第一部分的结

2、论。关键词血清糖基化白蛋白（GA），糖尿病，肾功能，蛋白尿INVESTIGATIONOFTHERELATIONSHIPBETWEENGLYCATEDALBUMINANDKIDNEYDISEASEWITHTYPE2DIABETESMELLITUSABSTRACTDiabetesmellitusisarampantdiseasewithmicrovascularcomplicationsincludingrenaldamage.Amadori-typeearlyglycationproductsandadvancedglycationend-productshavebeenshowntobecl

3、oselyassociatedwithdiabeticcomplications.Thepresentstudyaimedtoinvestigatetherelationshipbetweenserumglycatedalbuminlevelandkidneydiseaseseverityinpatientswithtype2diabetesmellitus.Inthefirstpart,weexploredthepossibleassociationbyanalyzingserumglycatedalbuminlevelindiabeticpatientswithvaryingrenalf

4、unction.153patientswithvaryingrenalfunctionandtype2diabetesmellituswereincludedandaccordingtothecreatinineclearance(Ccr)，weredividedintofourgroups:groupB(Ccr＞90ml/min,n=18)，groupC(Ccr60-90ml/min，n=61)，groupD(Ccr30-60ml/min，n=62)andgroupE(Ccr≤30ml/min，n=12).98normalpersonswereservedascontrols(groupA

5、),whowerereceivingroutineannualhealthexaminationinourhospital.Glycatedalbuminaswellasbiochemicalmeasurements(liverfunctiontest,kidneyfunctiontest,lipid,glucoseandHbA1c)wereanalyzedinallgroups.StatisticalanalysisshowedthatserumglycatedalbuminlevelwassignificantlydifferentamonggroupA(14.78±1.64%)，gro

6、upB(16.87±4.27%)，groupC(16.37±4.00%)，groupD(17.03±3.41%)andgroupE(19.32±4.26%).HbA1clevelwasshowingobviousdifferencebetweengroupAandgroupC,groupDandgroupE.AlthoughHbA1candglycatedalbuminlevelsbothreflectedglycemiccontrolinpatientswithdiabetes,glycatedalbuminwassignificantlyassociatedwiththerenalfun

7、ctioninpatientswithdiabetics(r=–0.168,P<0.05).Inthesecondpart,wefurtherstudiedtherelationshipbetweenserumglycatedalbuminlevelandthepresenceandseverityofproteinuriainpatientswithdiabetes.Controlgroupincluded