苦参碱和槐定碱对神经可塑性的影响

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1、宁夏医科大学硕士学位论文英文摘要interpulseintervals(IPIs)from20to1000ms.Result:(1)Matrinecansignificantlyinhibitthebasalsynaptictransmissionbothinpopulationspike(PS)amplitudeandtheslopeofpopulationexcitatorypostsynapticpotential(pEPSPslope).MatrinecanalsoinhibittheinductionofLTPinP

2、Samplitude,buthadnosignificanteffectonpEPSPslope.Matrinealsohadnosignificanteffectontheresponsestopaired-pulsestimulation.TheinhibitoryeffectofmatrineonLTPinductionwasstillobservedwhentheratsweretreatedwithatropinebeforehand.Ontheotherhand,itwasnotobservedafterthera

3、tsweretreatedwithnaloxonepreviously.(2)SophoridinecansignificantlyincreasethebasalsynaptictransmissioninPSamplitudeafterintraperitonealadministration,buthadnosignificanteffectinpEPSPslope.SophoridinecansignificantlyincreasepEPSPslopeafterLTPinduction,buthadnoeffecti

4、nPSamplitude.Inaddition,sophoridinehadinhibitoryeffectontheresponsetopaired-pulsestimulation.Conclusion:Theresultssuggestthatmatrineinhibitsthebasalsynaptictransmissionandlong-termsynapticplasticityinPSamplitude,butnotshort-termsynapticplasticityinthedentategyrus.Ma

5、trineexertsitsinhibitoryeffectonLTPinductionmightberelatedtotheactivationofopioidreceptorsinDG.Ontheotherhand,sophoridinecanpromotethebasalsynaptictransmissioninPSamplitudeandtheinductionofLTPinpEPSPslope.Itispossiblethatincreasingneurotransmitterreleaseandelevating

6、theefficacyofthesynapticprocessispartlyresponsibleforthePPSinhibitioninducedbysophoridine.KEYWORDS:matrine;sophoridine;neuralplasticity;long-termpotentiation(LTP);paired-pulsestimulation;evokedpotential-6-宁夏医科大学硕士学位论文英文摘要PARTTWOObjective:Toinvestigatetheepilepticsei

7、zure-likeeffectofsophoridineonelectro-encephalography(EEG)anditspossiblecharacteristicandthemechanismoftheseizure-likeeffect.Method:ChronicelectronimplantationwasemployedforIEEGrecordinginrat;andthetraditionalanti-seizuredrugswereforthemechanismstudyinmice.Result:Co

8、mparedwiththePPareaandTC,thegranulecellinDGisthemostsensitiveareainthekindlingeffectbys.c.sophoridine.Under-thresholdhypnoticdosageofdiaze