欢迎来到天天文库
浏览记录
ID:25884760
大小:3.32 MB
页数:99页
时间:2018-11-23
《苦参碱和槐定碱对神经可塑性的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、宁夏医科大学硕士学位论文英文摘要interpulseintervals(IPIs)from20to1000ms.Result:(1)Matrinecansignificantlyinhibitthebasalsynaptictransmissionbothinpopulationspike(PS)amplitudeandtheslopeofpopulationexcitatorypostsynapticpotential(pEPSPslope).MatrinecanalsoinhibittheinductionofLTPinPSamplitude,buthadnosign
2、ificanteffectonpEPSPslope.Matrinealsohadnosignificanteffectontheresponsestopaired-pulsestimulation.TheinhibitoryeffectofmatrineonLTPinductionwasstillobservedwhentheratsweretreatedwithatropinebeforehand.Ontheotherhand,itwasnotobservedaftertheratsweretreatedwithnaloxonepreviously.(2)Sophori
3、dinecansignificantlyincreasethebasalsynaptictransmissioninPSamplitudeafterintraperitonealadministration,buthadnosignificanteffectinpEPSPslope.SophoridinecansignificantlyincreasepEPSPslopeafterLTPinduction,buthadnoeffectinPSamplitude.Inaddition,sophoridinehadinhibitoryeffectontheresponseto
4、paired-pulsestimulation.Conclusion:Theresultssuggestthatmatrineinhibitsthebasalsynaptictransmissionandlong-termsynapticplasticityinPSamplitude,butnotshort-termsynapticplasticityinthedentategyrus.MatrineexertsitsinhibitoryeffectonLTPinductionmightberelatedtotheactivationofopioidreceptorsin
5、DG.Ontheotherhand,sophoridinecanpromotethebasalsynaptictransmissioninPSamplitudeandtheinductionofLTPinpEPSPslope.ItispossiblethatincreasingneurotransmitterreleaseandelevatingtheefficacyofthesynapticprocessispartlyresponsibleforthePPSinhibitioninducedbysophoridine.KEYWORDS:matrine;sophorid
6、ine;neuralplasticity;long-termpotentiation(LTP);paired-pulsestimulation;evokedpotential-6-宁夏医科大学硕士学位论文英文摘要PARTTWOObjective:Toinvestigatetheepilepticseizure-likeeffectofsophoridineonelectro-encephalography(EEG)anditspossiblecharacteristicandthemechanismoftheseizure-likeeffect.Method:Chroni
7、celectronimplantationwasemployedforIEEGrecordinginrat;andthetraditionalanti-seizuredrugswereforthemechanismstudyinmice.Result:ComparedwiththePPareaandTC,thegranulecellinDGisthemostsensitiveareainthekindlingeffectbys.c.sophoridine.Under-thresholdhypnoticdosageofdiaze
此文档下载收益归作者所有