资源描述：
《倍他司汀治疗眩晕的研究进展论文》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、倍他司汀治疗眩晕的研究进展论文摘要目的：分析倍他司汀作用机理及临床应用的研究进展。方法：在对其作用机制全面分析的基础上，对国外临床研究进行综述。结果与结论：从近20年的研究成果来看，倍他司汀作为一个组胺H1受体的弱激动剂，H3受体的强拮抗剂，对各种程度及发作频率的眩晕、头晕、不平衡的症状均能有效控制，并能显著改善局部脑血流量。其毒副作用也较其他抗眩晕药低，并有长期用药作用不减退的特点。倍他司汀是梅尼埃病和其他前庭性眩晕维持治疗有效的药物，并可用于治疗头晕、大脑局部供血不足。STUDYADVANCESOFBETAHIS
2、TINEINTREATMENTOFVERTIGOABSTRACTOBJECTIVE:Themechanism,clinicaluseandstudyadvancesofbetahistineineH1receptoragonistandastronghistamineH3receptorantagonist.Fromtheachievementofthelatetentofvertigo,dizzinessandunbalanceofvariousdurationandseverity,andcerebralbloo
3、dfloprovedbyit.ItsADRsislostreatment.KEY,GarbargeM,ThanhQuachT,etal.Actionsofbetahistineathistaminereceptorsinthebrain.EurJPharm,1985,.freelmermanH.HistamineH3ligands:justpharmacologicaltoolsorpotentialtherapeuticagents?JMedChem,1990,33(1)∶45TimmermanH.Histamin
4、eagonistsandantagonists.ActaOtolaryngol(Stockh),1991,479(Suppl)∶S56ArrangJM,DevauxB,Chodkieinereleaseinhumanbrain.JNeurochem,1988,51(1)∶1057Schinereceptortype：characterisation,localisationandfunctionsoftheH3-receptor.AgentActions，1990，30(1-2)∶138SerafinM,Khateb
5、A,VibertN,etal.Medialvestibularnucleusintheguinea-pig:histaminergicreceptors.I.Aninvitrostudy.ExpBrainres,1993,93(2)∶2429LaurikainenEA,MillerJM,QuirkenonG,ReynoldsA,etal.Betahistinehydrochloride(Serc)incerebrovasculardisease:aplacebo-controlledstudy.AgeAgeing,1
6、977,6(3)∶17911UnemotoH,SasaM,TakaoriS,etal.InhibitoryeffectofBetahistineonpolysynapticneuronsinthelateralvestibularnucleus.Archotorhinolaryngol,1982,236(3)∶22912B.Effectsofhistamineandbetahistineonratmedialvestibularnucleusneurones:possiblemechanismofactionofan
7、ti-histaminergicdrugsvertigoandmotionsickness.ExpBrainRes,1995,105(1)∶1813TighiletB,LeonardJ,LacourM.Betahistinedihydrochloridetreatmentfacilitatesvestibulapensationinthecat.JVestibRes,1995,5(1)∶5314LaurikainenE,HussainS,MillerJM,etal.Non-specificeffectofBetahi
8、stineoncochlearelectrophysiologyinguineapig.ActaOtolaryngol(Stockh),1997,529(Suppl)∶S7715FraysseB,BebearJP,DubreuilC,etal.Betahistinedihydrochlorideversusflunarizine.Adouble
