资源描述：
《a型肉毒毒素抑制大鼠变应性鼻炎鼻溢及vip在鼻腔粘膜的免疫表达论文》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、A型肉毒毒素抑制大鼠变应性鼻炎鼻溢及VIP在鼻腔粘膜的免疫表达论文文卫东侯一平袁芳王荫椿宋焱峰【关键词】BTXInhibitionofrhinorrheatoxintypeAandtheexpressionofVIPonnasalmucosainallergicrhinitisrat【Abstract】AIM:TostudytheeffectofBotulinumtoxinA(BTXA)oninhibitionofrhinorrhea,expressionandmorphologicalchangeofVasoactiv
2、eintestinalpolypeptide(VIP)atnasalmucosa,inallergicrhinitis(AR)rats.METHODS:Ovalbuminsensitizedtherattoestablishallergicrhinitismodel.Ratsmunoreactivityatnasalmucosaintheallergicrhinitisratsmunohistochemistry.Themorphologicalchangesatnasalmucosaethods.RESULTS:The
3、symptomsofallergicrhinitis,nasalrhinorrheaandsneezing,arkablyaugmentedafterovalbuminapplication.ThenasalrhinorrheasymptomdiminishedafterBTXAtreatment.ThequantityofnasalsecretionptominAR+BTXAgroupatoxylinandeosinstainingdemonstratedthatnoedema,smallvesselsa,vasodi
4、lationalandinflammationcellinfiltrationmunohistochemicalstudyrevealedthatVIPimmunoreactivefibersatthenasalmucosadecreasedmarkedlyafterBTXAapplication,butalargenumberofVIPfibersentisaselectiveandnontraumaticmethodtoreducealonglastingdesensitizationofthenasalmucosa
5、，toalleviatenasalcongestion，rhinorrheaandsneezing,andtoreducethesensoryneuronsensitivityofthemucosa.【Keyin）致敏.Distributionandquantityofneuroendocrinemarkersinallergicrhinitis［J］.ActaOtolaryngol,1998;118(3):398-403.［2］FangSY,ShenCL.Neuropeptideinnervationandneuroe
6、ndocrinecellsinallergicrhinitisandchronichypertrophicrhinitis［J］.ClinExperimentalAllergy,1998;28(2):228-232.［3］Rosenentofallergicrhinitis［J］.AmJMed,2002;16(113Suppl9A):S17-S24.［4］BousquetJ.Allergicrhinitisasaglobalhealthproblem［J］.ACIInt,200l;13:13.［5］NaumannMK,L
7、otoxintypeAonqualityoflifemeasuresinpatientsizedcontrolledtrial［J］.BrJDermatol,2002;147(6):1218-1226.［6］SuskindDL,TiltonA.ClinicalstudyofbotulinumAtoxininthetreatmentofsialorrheainchildrentoxintypeAinjectionintreatedtorticollispatientsparedentofparotidsialoceleto
8、xin［J］.Laryngoscope,1999;109:1344.［9］ElliesM,LaskaahlenG,GotzaxillofacSurg,2000;58:1251-1256.［10］ElliesM,LaskaahlenG.Immunohistochemicalandmorphometricinvestig
