血小板生长因子对新生鼠缺血缺氧性脑损伤保护作用论文

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1、血小板生长因子对新生鼠缺血缺氧性脑损伤保护作用论文【摘要】目的探讨血小板生长因子(PDGF)对新生鼠缺血缺氧性脑损伤(HIBD)的保护作用。方法7日龄ethodsThisstudyconsistedof72ANCOULTERFC500流式细胞仪，LD52A离心机(北京医用离心机厂制造)，日本OLYMPUS荧光显微镜，200目不锈钢细胞筛。1.2实验方法1.2.1新生大鼠HIBD模型制备治疗组和对照组制备HIBD模型。取7日龄MJ,SMITSA,FUNAK,etal.Differentialeff

2、ectsofplateletderivedgropalandcorticalgrafts:evidencefromintraoculartransplantationinratsJ.NeurosciLett,1992,136:227231.3OTHBERGA,ODINP,BALLAGIA,etal.SpecificeffectofplateletderivedgroandopaminergicneuronsinvitroJ.ExplBrainRes,1995,105:111122.4SMI

3、TSA,BALLAGIAE,FUNAK.PDGFBBexertstrophicactivityonculturedGABAinterneuronsfromtheneJ.EurJNeurosci,1993,5:986994.5SMITSA,KATOM,ARKB,etal.NeurotrophicactivityofplateletderivedgroiaondifferentneuralcellsinsubventricularzoneofhumanfetusJ.ZhonghuaErKeZaZ

4、hi,2008,46(9):644647.7金汉珍,黄德珉,官希吉.实用新生儿学M.3版.北京:人民卫生出版社,2003:400406.8MORIOKAI,TSUNEISHIS,TAKADAS,etal.PDGFαreceptorexpressionfolloicinjuryintheneonatalratbrainJ.KobeJMedSci,2004,50(1/2):2130.9OHNOM,SASAHARAM,NARUMIYAS,etal.Expressionofplateletder

5、ivedgroicencephalopathyofneonatalratsJ.Neuroscience,1999,90(2):643651.10IIHARAK,SASAHARAM,HASHIMOTON,etal.InductionofplateletderivedgroiaofratbrainJ.JCerebBloodFloactivationofplateletderivedgroodulatesthelatephaseofthehypoxicventilatoryresponseJ.JN

6、eurochem,2000,74(1):310319.12ERLANDSSONA,ENARSSONM,FORSBERGNILSSONK.ImmatureneuronsfromSstemcellsproliferateinresponsetoplateletderivedgrohumanneurospheresJ.NatBiotechnol,2001,19(5):475479.14VANHEYNINGENP,CALVERAR,RICHARDSONSKD,STRAFFDJ,ROBINSONMB

7、.Plateletderivedgroatetransporterthroughactivationofphosphatidylinositol3kinaseJ.JBiolChem,2000,275(7):52285237.16CHENGB,MATTSONMP.PDGFsprotecthippocampalneuronsagainstenergydeprivationandoxidativeinjury:evidenceforinductionofantioxidantpathofthera

8、tpreventshypoxiainducedapoptosisviaactivationofAktandBADJ.BrainRes,2001,895(1/2):111118.18NIKKHAHG,ODINP,SMITSA,etal.PlateletderivedgrootessurvivalofratandhumanmesencephalicdopaminergicneuronsincultureJ.ExplBrainRes,1993,92:516523.