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时间:2018-11-16
《大鼠慢性压迫性脊髓损伤及减压后神经营养素的表达论文》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、大鼠慢性压迫性脊髓损伤及减压后神经营养素的表达论文.freelal,chronicpressivespinalcordinjury,depressionandcontrolgroups.Im-munohistochemicalmethodesignifi-cantchanges.paredalandcontrolgroups,1dafterpression,thelabelingindexesaland30-day-pressivegroups,1dafterdepression,thelabelingindex-eseprotectiveeffectonchronicpressive
2、spinalcordinjury.Depressionrelievesthenerveinjuryandprotectsthenervefunctionbyactivatingneurotrophins.0引言创伤日益常见,伤及脑脊髓者不少,后果严重.目前脑脊髓损伤后的保护和修复方面的研究取得了令人瞩目的成果[1-4].慢性脊髓压迫性疾病是神经系统常见疾患,如肿瘤和各种原因所致的椎管狭窄,是一组具有占位性特征的椎管内病变[5].病理上具有缺血和创伤两方面的改变.大量研究表明[6,7]脊髓损伤后,神经营养素(neurotrophins)及其受体表达明显增加,神经营养因子受体(neurot
3、rophicfactorsre-ceptor,NTFR)在损伤脊髓的轴突及神经胶质的反应方面也起重要作用,神经营养因子(Neurotrophicfactors,NTF)对脊髓损伤后的恢复产生着重要的作用[8].我们设计了后路渐进慢性压迫性脊髓损伤动物模型,应用免疫组织化学方法检测了不同程度慢性压迫性脊髓损伤后及减压后神经营养素及其受体表达的变化规律.1材料和方法1.1材料体质量300~350g的雄性,XuLX,C.Pro-tectiveeffectofpuerarinonspinalcordinjuryresultingfromis-chemiaandreperfusioninrabb
4、its[J].Di-siJunyiDaxueXue-bao(JFourthMilMedUniv),2001;22(5):414-417.[2]HeYD,FeiZ,ZhangX,HeXS,LiSH,LiangJCPG[J].Di-siJunyiDaxueXuebao(JFourthMilMedUniv),2001;22(7):612-615.[3]ChenLG,PiaoYX,ZengFJ,GaoLD,MaoBY,YangLB,HuangMQ,HuicrogenepSVPoMcatimplantedtomod-ifyschechanismofadrenosensitityinchronic
5、allypresseddorsalrootgan-glionneuronsinrats[J].Di-siJunyiDaxueXuebao(JFourthMilMedUniv),1999;20(7):566-569.[6]HayashiM,UeyamaT,NemotoK,TamakiT,SenbaE.Se-quentialmRNAexpressionforimmediateearlygenes,cy-tokines,andneurotrophinsinspinalcordinjury[J].JNeuro-traum,2000;17(3):203-218.[7]XiongG,LuoYX.T
6、heinfluenceofneurotrophinsafterratspinalcordhemisection[J].ZhonghuaXianotingsur-vivalofdorsalrootgangliabyadenoviral-mediatedneurotrophic-3expressioninvitro[J].Di-siJunyiDaxueXuebao(JFourthMilMedUniv),2001;22(11):965-967.[9]KrenzNR,J,FrerichsF,DonnanGA,Hoacrophasesandmi-crogliainducedopaminergic
7、spoutingintheinjuredstriatumandexpressbrian-derivedneurotrophicfactorandglialcellline-de-rivedneurotrophicfactor[J].JNeurosci,1999;19(5):1708-1716.[11]ZhangQ,Liao,ChengHS,LiYY.Theeffectofneurotrophinstospinalcordinjuryinrats
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