ngal在原发性干燥综合征患者血清及尿液中的表达及意义

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1、授予单位代码10089学号或申请号20153151中国图书分类号R593.2HebeiMedicalUniversity硕士学位论文专业学位NGAL在原发性干燥综合征患者血清及尿液中的表达及意义研究生：贡小昕导师：郭惠芳教授专业：内科学二级学院：河北医科大学第二医院2018年3月目录中文摘要····································································································1英文摘要·················································

2、···················································2英文缩写····································································································4研究论文NGAL在原发性干燥综合征患者血清及尿液中的表达及意义前言·····································································································5材料与方法···

3、······················································································6结果·····································································································9附图···································································································12附表····

4、·······························································································16讨论···································································································20结论··································································································

5、·23参考文献···························································································23综述干燥综合征继发间质性肾损害生物学标记物研究进展······27致谢············································································································33个人简历···················································

6、················································34中文摘要NGAL在原发性干燥综合征患者血清及尿液中的表达及意义摘要目的：本研究通过检测原发性干燥综合征（primarySjögren’ssyndrome，pSS）患者血清及尿液中中性粒细胞明胶酶相关脂质运载蛋白（neutrophilgelatinase-associatedlipocalin，NGAL）的表达，分析NGAL与患者临床、实验室指标的相关性，探讨NGAL在pSS患者病情评估中的作用及意义。方法：选取门诊及住院pSS患者37例为pSS组，年龄、性别相匹配的30例健康人作为健康对照组。记

7、录所有pSS患者的临床症状、体征及实验室检查指标。采用胶乳增强免疫比浊法检测pSS组及健康对照组血清及尿液中NGAL的表达。比较健康对照组及pSS组NGAL表达水平的差异，并分析NGAL与临床、实验室各项指标的相关性。所有数据输入SPSS24.0进行统计分析。结果：pSS组血清NGAL及尿液NGAL水平均高于健康对照组（P＜0.05）。有肾损害组与无肾损害组两组之间血清及尿液NGAL表达水平均无统