ngal在子痫前期患者血液、尿液及胎盘组织中的表达及临床意义

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1、授予单位代码10089学号或申请号13270tCMHebeiMedicalUniversity硕士学位论文在职科学学位NGAL在子痫前期患者血液、尿液及胎盘组织中的表达及临床意义学位申请人：宋玉杰导师.•陈铎教授专业：妇产科学二级学院：第二医院2015年3月5可北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的

2、论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。.•••W研究生签名+1导师签章二级学院领导盖章：年r月^[日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：x年夕月曰目录中文摘要····························

3、·················································1英文摘要·············································································5研究论文NGAL在子痫前期患者血液、尿液及胎盘组织中的表达及临床意义前言·············································································9材料与方法·

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5、··························································22讨论·············································································24结论·············································································28参考文献··························

6、·············································28综述中性粒细胞明胶脂酶相关脂质运载蛋白与子痫前期的研究进展·31致谢···················································································38个人简历·············································································39中文摘

7、要NGAL在子痫前期患者血液、尿液及胎盘组织中的表达及临床意义摘要目的：妊娠期高血压疾病（hypertensivedisorderscomplicatingpregnancy，HDP）是妊娠期间伴随血压升高的一组疾病，包括妊娠期高血压、子痫前期、子痫以及慢性高血压并发子痫前期和慢性高血压合并妊娠。其发病机制到目前为止还不确定，普遍认为是由于多种因素和多种途径共同导致妊娠期高血压疾病的发生，而母体机体弥漫性血管内皮细胞的激活和(或)损伤是其发病的重要原因，但目前对内皮细胞激活和损伤的机制尚不清楚，如果

8、能通过血管内皮细胞的损伤情况，来判断妊娠期高血压疾病发生和发展的程度，对临床上防治妊娠期高血压疾病是十分关键的。中性粒细胞明胶酶相关脂质运载蛋白(neutrophilgelatinase-associatedlipoealin，NGAL)属于脂蛋白(lipoealin)家族的成员之一，它对多种细胞的增殖、生长和分化具有促进作用，可以降解组织中的胶原和蛋白成分，当机体的局部组织出现炎症或肿瘤时，NGAL的含量会明显增加，有研究表明NGAL是评价因炎症或肿瘤形成而导致内皮