icos、bcl-6蛋白在原发性干燥综合征外周血及唇腺组织中的表达及意义

《icos、bcl-6蛋白在原发性干燥综合征外周血及唇腺组织中的表达及意义》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20丨23019HebeiMedicalUniversity硕士学位论文专业学位�COS�Bd-6蛋白在原发性干燥综合征外周血及唇腺组织中的表达及意义研究生：常晓华导师：郭惠芳教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北

2、医科大学所有。否则，承担相应的法律责任。,河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包含其他人已发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名:导师签章_寧4_年I月》j目录中文摘要·············································································1英文摘要·························································

3、····················5英文缩写·············································································10研究论文ICOS、Bcl-6蛋白在原发性干燥综合征外周血及唇腺组织中的表达及意义前言·············································································11材料与方法······························································

4、······11结果·············································································17附图·············································································20附表·············································································25讨论·······································

5、······································27结论·············································································29参考文献·······································································31综述滤泡型辅助性T细胞对生发中心B细胞转归的影响··············34致谢····················································

6、·······························43个人简历·············································································44中文摘要ICOS、Bcl-6蛋白在原发性干燥综合征外周血及唇腺组织中的表达及意义摘要干燥综合征(sjogren’ssyndrome,SS)是以口眼干燥、泪液唾液分泌减少，可累及多脏器为临床表现，以淋巴细胞高度浸润为病理特点的弥漫性结缔组织病，分为原发性和继发性。原发性干燥综合征(primarysjogren’ssyndromePSS)从发病到病变迁延

7、的基础是免疫功能紊乱，外分泌腺管道上皮细胞可发挥抗原递呈作用，细胞识别抗原后T、B细胞增殖，促使B细胞分化为浆细胞，进而产生大量免疫球蛋白、自身抗体，导致体液免疫过度的异常反应，聚集大量的各种细胞因子和炎症介质造成组织损伤。在此过程中有一类CD4+T细胞亚群，辅助B细胞，以趋化因子受体CXCR5为主要表面标志物，高表达特异性ICOS、BCL-6、CD40、PD-1，分泌IL-21发挥其生物学功能，起着不可或缺的作用，这类细胞称为滤泡辅助性T细胞(follicularhelperTcell,T