沙库巴曲缬沙坦对射血分数降低的心力衰竭患者心功能的影响

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1、授予单位代码10089学号或申请号20153179中国图书分类号R541.4HebeiMedicalUniversity硕士学位论文专业学位沙库巴曲缬沙坦对射血分数降低的心力衰竭患者心功能的影响研究生吴明明导师郝国贞教授傅向华教授专业内科学二级学院河北医科大学第二医院2018年3月目录中文摘要········································································································1英文

2、摘要··········································································································2英文缩写···········································································································4研究论文沙库巴曲缬沙坦对射血分数降低的心力衰竭患者心功能的影响前言

3、············································································································6材料与方法··························································································7结果···············································

4、···························································10附图··········································································································13附表·················································································

5、·························15讨论··········································································································19结论··········································································································22参考文献···

6、······························································································23综述沙库巴曲缬沙坦在心力衰竭中的研究进展·····················································25致谢·················································································

7、···························35个人简历····································································································36中文摘要沙库巴曲缬沙坦对射血分数降低的心力衰竭患者心功能的影响摘要目的:探讨沙库巴曲缬沙坦与盐酸贝那普利对射血分数降低的心力衰竭（HFrEF）患者治疗后1个月心功能的影响。方法:入选2017年12月-2018年2月在我科住院治疗的射血分数

8、降低的心力衰竭患者40例为研究对象，随机分为盐酸贝那普利组和沙库巴曲缬沙坦组。两组患者分别给予抗心衰常规治疗。对照组给予盐酸贝那普利（洛丁新北京诺华制药有限公司）10mg口服每日1次治疗。试验组在停止ACEI36小时后或ARB24小时后转换为沙库巴曲缬沙坦（诺新妥北京诺华制药有限公司）50mg口服每日2次，每2周剂量倍增1次，直到目标剂量200mg口服每日2次。结果：盐酸贝那普利组治疗1个月后NT-proBNP水平、E/A、E/e´、收缩压