ph响应性peg化壳聚糖基隐形纳米胶束的制备及其释药分析

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1、华侨大学硕士学位论文behaviorofdrug-loadedmicelleshadacertainpHsensitivity.PEDACScouldformthesmallerstealthmicelleswhichachievedthelong-circulatingofbody.AndtherangeofpHresponsewasrightlyfittothegrowthmicroenvironmentoftumorcell(pH7.2～6.0).Itwouldbeexpectedtobecomeanewmaterialofdrugdeliverysystem.Keywords

2、:AmphiphilicchitosanmPEGpH-responsiveStealthnano-micellesIV万方数据目录目录第1章绪论.......................................................................................................11.1壳聚糖和甲壳素简介..............................................................................11.2壳聚糖的主要改性.................

3、.................................................................21.2.1烷基化改性.......................................................................................21.2.2聚乙二醇(PEG)化改性.....................................................................41.2.3酰化改性...................................

4、........................................................51.3PEG化隐形纳米脂质体..........................................................................61.4聚合物“智能型”纳米胶束.......................................................................81.4.1聚合物胶束简介..................................................

5、.............................81.4.2聚合物胶束的医用特点...................................................................81.4.3智能型纳米胶束...............................................................................81.5本课题研究内容的提出........................................................................13第2章

6、N,N-双烷基-3,6-O-mPEG-壳聚糖的制备及表征..............................172.1引言........................................................................................................172.2实验部分................................................................................................172.2.1主要试剂和仪器.......

7、......................................................................172.2.2mPEG-COOH的制备.....................................................................182.2.3N,N-双烷基壳聚糖(DACS)的制备..............................................