慢性丙型肝炎患者血清白细胞介素-26水平变化及意义

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1、授予单位代码10089学号或申请号15004中国图书分类号R575.1HebeiMedicalUniversity硕士学位论文学术学位慢性丙型肝炎患者血清白细胞介素-26水平变化及意义研究生：柳静文导师：赵彩彦教授专业：内科学二级学院：第三医院2018年03月目录中文摘要··········································································································1英文摘要······························

2、············································································3英文缩写··········································································································6研究论文慢性丙型肝炎患者血清白细胞介素-26水平变化及意义前言··························································

3、················································7材料与方法······························································································8结果··········································································································10附图················

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5、·································19结论··········································································································22参考文献··································································································22综述慢性丙型病毒性肝炎的肝外表现············

6、··········································25致谢··················································································································37个人简历··········································································································38慢性丙

7、型肝炎患者血清白细胞介素-26水平变化及意义摘要目的：慢性HCV感染是造成慢性肝脏损伤的重要原因之一。研究证明，丙型肝炎肝损害的主要原因是HCV感染后引起的免疫学应答，其中细胞毒性T淋巴细胞(CTL)起重要作用，但感染慢性化机制尚未阐明。白细胞介素26（IL-26）是IL-10细胞因子家族的成员，其基因表达与功能对T细胞具有高度特异性。IL-26可以在炎性细胞中过表达，诱导骨髓细胞和一些上皮细胞产生促炎细胞因子，造成组织损伤。但在慢性HCV感染中IL-26的变化如何，在慢性HCV感染的疾病进展中发挥何种作用，尚未阐明。因此，本研究旨在通过观察慢性丙

8、型肝炎患者血清中IL-26表达水平并与健康对照组进行比较，评价IL-26表达与肝脏炎症活动程度相关性，对比直接抗病毒药物治