前列腺周围脂肪与前列腺癌侵袭性的相关性研究

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1、授予单位代码10089学号或申请号20153310中国图书分类号R445.2HebeiMedicalUniversity硕士学位论文专业学位前列腺周围脂肪与前列腺癌侵袭性的相关性研究研究生：安琪导师：肖志军教授专业：影像医学与核医学二级学院：河北医科大学第二医院2018年3月目录中文摘要················································································1英文摘要·····································

2、···········································2研究论文前列腺周围脂肪与前列腺癌侵袭性的相关性研究前言················································································4材料与方法·······································································5结果···································

3、·············································7附图················································································8附表··············································································11讨论·····················································

4、·························13结论··············································································19参考文献········································································19综述肥胖与前列腺癌关系的研究进展·······································24致谢····················

5、································································36个人简历··············································································37中文摘要前列腺周围脂肪与前列腺癌侵袭性的相关性研究摘要目的：在磁共振（MRI）图像上测量前列腺周围脂肪体积（PFV）及前列腺总体积（TPV），并计算前列腺周围脂肪比例（前列腺周围脂肪体积/前列腺体积，P/T），评估P/T与前列腺癌侵

6、袭性的相关性。方法：回顾性分析在我院确诊的前列腺癌患者80例，将前列腺癌患者按Gleason评分分为低级别（GS=6）和高级别（GS≥7）两组。同时选取非前列腺癌30例做为对照组。在MRI图像上测量皮下脂肪厚度（SFT）、PFV、TPV，计算P/T比值。并收集受检者的临床病理资料。比较前列腺癌组与对照组间脂肪测量指标的差异，分析脂肪测量指标与体重指数（BMI）、Gleason评分的相关性，以及高级别前列腺癌的独立危险因素。结果：1.前列腺癌组P/T及首诊血清前列腺特异性抗原（PSA）均高于对照组（P＜0.01），高级别组P/T

7、、PSA高于低级别组（P＜0.01），而各组间SFT、BMI、年龄差异没有统计学意义（P＞0.05）。2.Gleason评分与P/T、PSA（r=0.561，P=0.000；r=0.532，P=0.000）呈正相关。Gleason评分与年龄、BMI、SFT无明显相关性（P＞0.05）。3.多因素Logistic回归分析显示，P/T是高级别前列腺癌的独立危险因素之一（P=0.02，OR：1.371）。4.SFT与BMI之间呈正相关（r=0.645，P=0.000），而PFV、P/T与BMI之间无明显相关性（P＞0.05）。结论：

8、前列腺周围脂肪比例（P/T）的增大与前列腺癌侵袭性有相关性，P/T是高级别前列腺癌的独立危险因素之一。通过MRI图像上前列腺周围脂肪的测量可以对前列腺癌恶性程度进行预测，为预后提供意见。关键词：前列腺癌,Gleason评分,前列腺周围脂肪,内脏脂肪,皮下脂肪1英文摘要Corr