血清尿酸水平与急性缺血性脑卒中预后的关系

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1、授予单位代码10089学号或申请号20153222中国图书分类号R743.3HebeiMedicalUniversity硕士学位论文专业学位血清尿酸水平与急性缺血性脑卒中预后的关系研究生：陈新颖导师：郭书英教授专业：神经病学二级学院：河北医科大学第二医院2018年3月目录中文摘要··········································································································1英文摘要··········································

2、································································2英文缩写··········································································································4研究论文血清尿酸水平与急性缺血性脑卒中预后的关系前言···························································································

3、···············5材料与方法······························································································5结果··········································································································8附表··································································

4、········································10讨论··········································································································15结论··········································································································18参考文献···························

5、·······································································18综述血清尿酸水平与急性缺血性脑卒中预后的研究进展······················21致谢··················································································································30个人简历··················································

6、························································31中文摘要血清尿酸水平与急性缺血性脑卒中预后的关系摘要目的：通过研究尿酸水平与急性缺血性脑卒中预后的关系，旨在找到一个合理的尿酸范围。方法：本研究选取2017年01月至2018年01月在河北医科大学第二医院东院区神经内科住院的急性脑梗死患者302例，住院期间采集相关资料，包括性别、年龄、烟酒史以及脑血管病的常见危险因素、既往用药史、入院NIHSS评分，入院次日空腹采血测定血清尿酸值，并于出院后90天电话随访,依据mRS脑卒中量表对患者进行评分，并统计分析尿酸对预后是否

7、有影响。结果:1.急性缺血性脑卒中患者性别之间血清尿酸水平有差异，男性水平明显高于女性水平。2.以患者尿酸值的四分位间距分为4组，以尿酸水平为236umol/L-301umol/L做为参照组，尿酸值UA≤235umol/L和UA≥369umol/L的患者相较于基线组预后更差的风险高3-8倍。按性别进行分层研究，在男性患者中，尿酸值UA≥385umol/L组的患者相较于基线组预后更差的风险高6倍。女性患者，尿酸水平UA≥316umol/L的患者与尿酸水平UA≤208umol/L的患