颞叶神经元内质网应激在七氟烷引起老年大鼠认知功能下降中的变化

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1、授予单位代码10089学号或申请号16002中国图书分类号R322.8HebeiMedicalUniversity硕士学位论文学术学位颞叶神经元内质网应激在七氟烷引起老年大鼠认知功能下降中的变化研究生：王景川导师：李双成教授王新生教授专业：人体解剖与组织胚胎学二级学院：基础医学院2018年3月目录中文摘要············································································································1英文摘要···························

2、·················································································3英文缩写············································································································6研究论文颞叶神经元内质网应激在七氟烷引起老年大鼠认知功能下降中的变化前言······························································

3、··············································7材料与方法································································································8结果··········································································································16附图································

4、··········································································18附表··········································································································26讨论·········································································································

5、·27结论··········································································································29参考文献··································································································30综述七氟烷对术后认知障碍的影响及与内质网应激相关性····················34致谢···························

6、·······················································································41个人简历··········································································································42颞叶神经元内质网应激在七氟烷引起老年大鼠认知功能下降中的变化摘要术后认知障碍（postoperativecognitivedysfunction，POCD）是临床上麻醉手术后常见的并发

7、症，注意力下降、记忆力受损、学习能力下降、思维语言受损等为主要表现。老年患者有很大部分发生了术后谵妄或者发展成为术后认知障碍，而且与远期痴呆有紧密联系。目前七氟烷在临床中被广泛应用，是较为理想的吸入麻醉药，易于各年龄病人接受。血/气分配系数较低、麻醉深度控制性较强，并有一定程度的肌肉松弛作用，在麻醉中可以做到快速诱导和苏醒。对于应用如此广泛的中枢神经系统药物，在不断地推广应用的同时，其用药安全性越来越成为人们关注的焦点。大量研究逐渐证实，七氟烷等吸入性麻醉药是存在神经毒性安全风险