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1、不同治则中药复方对胆汁淤积性肝纤维化大鼠尿激酶型【摘要】目的观察补益肝肾、活血化瘀方二至丸、失笑散及其合方对胆汁淤积性肝纤维化大鼠肝组织尿激酶型纤溶酶原激活剂(uPA)的影响。方法采用胆管结扎复制胆汁淤积性肝纤维化大鼠模型。造模大鼠于术后1周随机分为模型组、优思弗组、二至丸组、失笑散组及合方组；各药物干预组分别给予相应药物灌胃,模型组和假手术组给予等量生理盐水灌胃,至4周末处死全部动物取材。观察各组大鼠一般情况、肝功能(ALT、AST、ALP、TBil)、肝组织病理、uPA蛋白表达(ethodsBileductligationmethodakethemodelofcholes
2、tasis-inducedliverfibrosis.Onelydividedintofivegroup(modelgroup,UDCAgroup,Erzhiedicineinterventiongroupedicinebyintragastricadministration.Shamandmodelgroupchloridepled.Generalstateofhealth,hepaticfunction(ALT,AST,ALP,TBil)andpathologicalhistologyofhepatictissueeasured.Resultsparedgroup,the
3、levelofALT,AST,ALP,TBilandthedegreeofliverfibrosisinmodelgroupodelgroup,threeChineseherbalpounddecreasedserumlevelof 不同治则中药复方对胆汁淤积性肝纤维化大鼠尿激酶型【摘要】目的观察补益肝肾、活血化瘀方二至丸、失笑散及其合方对胆汁淤积性肝纤维化大鼠肝组织尿激酶型纤溶酶原激活剂(uPA)的影响。方法采用胆管结扎复制胆汁淤积性肝纤维化大鼠模型。造模大鼠于术后1周随机分为模型组、优思弗组、二至丸组、失笑散组及合方组；各药物干预组分别给予相应药物灌胃,模型组和假手术组
4、给予等量生理盐水灌胃,至4周末处死全部动物取材。观察各组大鼠一般情况、肝功能(ALT、AST、ALP、TBil)、肝组织病理、uPA蛋白表达(ethodsBileductligationmethodakethemodelofcholestasis-inducedliverfibrosis.Onelydividedintofivegroup(modelgroup,UDCAgroup,Erzhiedicineinterventiongroupedicinebyintragastricadministration.Shamandmodelgroupchloridepled.Gene
5、ralstateofhealth,hepaticfunction(ALT,AST,ALP,TBil)andpathologicalhistologyofhepatictissueeasured.Resultsparedgroup,thelevelofALT,AST,ALP,TBilandthedegreeofliverfibrosisinmodelgroupodelgroup,threeChineseherbalpounddecreasedserumlevelofALP,ALTandAST(P＜0.01).Shixiaosanandhefangdecreasedserumle
6、velofTBil(P＜0.01).HefangplerecipeonALPandALT.Threeherbalpoundreleasedliverfibrosistosomeextent(P＜0.01),andhefangplerecipe.UDCAdecreasedserumlevelofALTandAST,buthadnoeffectonliverfibrosis.paredodelgroup,uPAexpressionsignificantlyincreasedinthreeChineseherbalgroups(P＜0.01),andhefanggroupiddle
7、,Erzhiotingbloodcirculationandremovingbloodstasiscaninhibitthecholestasis-inducedliverfibrosis.ThemechanismMP)级联反应途径调控纤溶酶和MMP活性,影响细胞外基质(ECM)合成与降解,与肝纤维化关系密切。目前,肝纤维化中医基本病机属血瘀、正虚两方面的理论已基本达成共识。迄今,有关抗肝纤维化复方研究的立法组方主要集中活血化瘀和扶正(益气养血或补益肝肾)两大类的结合,活血化瘀结合扶正固本为中医药抗肝纤
