血管紧张素受体拮抗剂联合用药治疗高血压患者的疗效观察

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1、血管紧张素受体拮抗剂联合用药治疗高血压患者的疗效观江苏省泰兴市张桥卫生院225400【摘要】目的观察血管紧张素受体拮抗剂(ARB)联合β受体阻滞剂治疗高血压患者的临床疗效。方法选择泰兴市张桥卫生院全科门诊自2012年3月至2015年3月期间就诊的100例高血压患者，随机分为观察组和对照组，每组50例。观察组采用ARB联合β受体阻滞剂即缬沙坦和美托洛尔缓释片联合治疗；对照组采用钙拮抗剂(CCB)联合β受体阻滞剂即氨氯地平联合美托洛尔缓释片。观察和比较两组治疗后10周的收缩压、舒张压和心率变化情况以及症状改善情况。结果治疗10周后，两组收

2、缩压、舒张压和心率均较治疗前丁降显著，差异有统计学意义(P<0.05);观察组治疗10周后收缩压、舒张压与对照组比较，差异无统计学意义(P>0.05)；但治疗10周后心率和症状改善情况明显优于对照组，差异有统计学意义(P<0.05)。结论ARB联合β受体阻滞剂治疗高交感张力高血压患者，具有安全有效、不良反应少的优点，值得临床推广，尤其是在基层。【关键词】高血压；血管紧张素受体拮抗剂；β受体阻滞剂；钙拮抗剂；心率；收缩压；舒张压[Abstract]ObjectiveToobservetheclinicaleffectofangiotensinre

3、ceptorblockers(ARB)combinedwithbetablockersinthetreatmentofhypertension.Methods100patientswithhypertensionfromMarch2015toMarch2012wererandomlydividedintoobservationgroupandcontrolgroup,50casesineachgroup.TheobservationgroupwastreatedwithARBcombinedwithabetablockerorvalsartanandmetopro

4、lolsustained-releasetabletscombinedtreatment；controlgroupwithcalciumantagonists(CCB)combinedwithabetablockeroramlodipinecombinedwithmetoprololsustained-releasetablets.Thechangesofsystolicbloodpressure,diastolicbloodpressure，heartrateandtheimprovementofsymptomswereobservedandcomparedbe

5、tweenthetwogroupsafter10weeksoftreatment.ResultsAfter10weeksoftreatment,thesystolicbloodpressure,diastolicbloodpressureandheartrateofthetwogroupsweresignificantlylowerthanthosebeforetreatment,thedifferencewasstatisticallysignificant(P<0.05)；After10weeksoftreatment,thesystolicbloodp

6、ressureanddiastolicbloodpressureoftheobservationgroupwerecomparedwiththatofthecontrolgroup(P>0.05)；Butafter10weeksoftreatment，heartrateandsymptomimprovementweresignificantlybetterthanthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.05).ConclusionARBcombinedwithbetabl

7、ockersinthetreatmentofpatientswithhighbloodpressureandhypertension，hastheadvantagesofsafeandeffective，lessadversereactions，itisworthyofclinicalpromotion,especiallyatthegrassrootslevel.【Keywords】Hypertension;Angiotensinreceptorblockers；Betablockers；Calciumantagonists；Heartrate；Systolic

8、blood