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时间:2018-10-28
《替米沙坦联合丹参酮ⅱa治疗早期糖尿病肾病临床疗效观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、替米沙坦联合丹参酮IIA治疗早期糖尿病肾病临床疗效观梁峰翎刘虹(通讯作者)湖南省马王堆医院老年综合科410016摘要:目的:观察替米沙坦联合丹参酮IIA治疗早期糖尿病肾病的临床疗效。方法:选取符合1999年WHO糖尿病诊断标准及DN早期诊断标准的80例早期糖尿病肾病患者,随机分为对照组和治疗组,每组40例。两组均严格控制血糖和血压在正常范围,对照组单纯使用替米沙坦,治疗组在此基础上给予丹参酮IIA,检测治疗12周后患者尿微量白蛋白排泄率(UAER),尿微量白蛋白(MA),肾功能:尿素氮(BUN)、血肌酐(sCr),空腹血糖(FBG)。结果:治疗后,两组患者UAER、MA、BUN、S
2、Cr、FPG均有明显下降,差异均異有统计学意义(P<0.05);且治疗组总有效率高于对照组。用药过程中,个别患者出现滴注部位不适,减慢滴速后症状得到缓解。结论:替米沙坦联合丹参酮IIA治疗早期糖尿病肾病的疗效显著,可有效降低尿白蛋白排泄率,减少24h尿蛋白,改善肾功能,且不良反应少,值得临床推广。关键词:丹参酮IIA;替米沙坦;早期糖尿病肾病Methods80patientsdiagnosedearlydiabeticnephropathywhowereinaccordancewithWHOdiagnosisstandardin1999andDNearlydiagnosisstan
3、dardwereselectedanddividedintoastudygroupof40patientsconfirmedapplicationTelmisartanTanshinoneIIAtherapytreatment,thecontrolgroupof40petientsconfimedapplicationtreatment.Totaltreatmentfor12weeks.Thetwogroupswerestrictlycontrolledbloodglucoseandbloodpressureinthenormalrange.theclinicalefficacyr
4、atewasobservedaftertreatmentfor12weeks.Andtheurinaryalbuminexcretionrate(UAER)、urinaryAlbumin/Renalfunction:ureanitrogen(BUN)、serumcreatinine(sCr)、fastingbloodglucose(FBG)wereobservedaftertreatmentfor12weeks.ResultsAfter12weeksoftreatment,theUAER,MA,SCr,BUN,FPGofthestudygroupandthecontrolgroup
5、decreasedthanbeforetreatment,andthedifferenceswerestatisticallysignificant(P<0.05);Thetotaleffectiverateofstudygroupwerehigherthanthatofcontrolgroup,andthedifferenceswerestatisticallysignificant(P<0.05).Duringtheprocessofthetreatment,individualpatientsshowedinfusionsitediscomfort,intrave
6、nousinfusionafterthesymptomshavebeenalleviated.Conclusion:EfficacyofTelmisartancombinedwithTanshinoneIIAinthetreatmentofpatientswithearlydiabeticnephropathyissignificant.Theycaneffectivelyreducetheurinaryalbuminexcretionrateandthe24hurinaryprotein,improverenalfunction,andlessadversereaction,is
7、worththeclinicalpromotion.KeywordsTanshinoneIIA;Telmisartan;earlydiabeticnephropathy0引言随着社会经济的发展,人们生活水平逐渐提高,饮食结构改变,运动量减少,生活节奏加快等生活方式的改变导致糖尿病发病率在全球范围内迅速增加。糖尿病肾病(diabeticnephropathy,DN)在糖尿病中的患病比例也逐年增加,是较严重的微血管并发症,是糖尿病致死的重要原因之一。DN治疗的关键在于早期
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