妊娠高血压患者的血脂变化及临床意义

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1、妊娠高血压患者的血脂变化及临床意义王磊雷晚红(咸宁市第一人民医院妇产科湖北咸宁437000)【中图分类号】R714.2【文献标识码】A【文章编号】1672-5085(2012)5-0100-03【摘要】目的探讨妊娠高血压患者血脂的变化及其临床意义。方法选择妊娠高血压患者、正常妊娠者、正常未孕者各40例，测定并比较血脂指标的变化。结果与正常未孕组相比，妊娠高血压疾病组和正常妊娠组血清TC、TG、HDL-C、LDL-C、ApoAl、ApoB、Lp(a)等指标均显著增高(P<0.01);妊娠高血压疾病组与正常妊娠组相比，TG、LDL-C、ApoB显著增高(P&

2、lt;0.01),而ApoAl却显著减低(p<0.01),TC和Lp(a)明显增高(p<0.05),而HDL-C却明显减低(p<0.05)。结论妊娠高血压孕妇存在明显的血脂代谢异常，妊娠期间定期监测LDL-C、ApoA/ApoB比值及Lp(a)的变化，对预测妊娠高血压的发生、发展有一定临床意义。【关键词】妊娠高血压疾病血脂载脂蛋白脂蛋白SerumLipidsChangesandlt’sClinicalSignificancesinPatientswithPregnance-inducedHypertensionWANGLei；LE

3、IWan-hong(DepartmentofGynecologyandObstetrics，FirstPeople’sHospitalofXianningCity,HubeiXianning437000)【Abstract】Objective：Toinvestigatetheserumlipidschangesandtheirclinicalsiginificanceinpatientswithpregnance-inducedhypertension.Methods：Thisstudywasdividedintopregnance-induced

4、hypertensiongroup,normalpregnaneygroupandnormalnon-pregnantgroup，therewere40casesineachgroup.Theserumlipidsweredeterminedandcomparedamongeachgroup.Results：Comparedwithnormalnon-pregnantgroup，theIvelelsofTC,TG,LDL-C,HDL-C,ApoAl,ApoBandLp(a)wereincreasedobviouslyinpregnance-inducedhyp

5、ertensiongroupandnormalpregnaneygroup(P<0.01).AndlevelsofTG,LDL-C,ApoBweresiginificantlyhigherinpregnance-inducedhypertensiongroupthannormalpregnaneygroup(P<0.01).WhileApoAlandHDL-Cweremarkedlyreduced,TCandLp(a)increasedclearly(P<0.05).Conclusions:Thereisobviousabnormallipidmetaboli

6、sminpatientswithpregnance-inducedhypertension.Therefor,ithascertainclinicalsignificancesofforecastingtheoccurrenceanddevelopingofpregnance-inducedhypertensionbymonitoringthechangesofserumlipidsduringpregnance，especiallythechangesofserumLDL-C，ApoAI/ApoBandLp(a).【Keywords】hypertensive

7、disordercomplicatingpregnancybloodlipidapolipoproteinlipoprotein妊娠期高血压疾病(hypertensivedisordercomplieatingpregnaney,HOCP)是妊娠期的特发疾病，可导致母体多脏器功能受损、胎儿生长受限、早产等不良围产结局，重者导致孕妇抽搐、&迷、颅内出血等严重并发症，是导致孕产妇和围产儿发病和死亡的主要原因，严重威胁孕妇及胎儿健康与生命，尤苏是早发性重度子痫前期的发生严重影响了围产期孕产儿的质量。苏发病原因0前尚不明确，本病的基本病理生理变化是全身小血管痉挛及各脏

8、器灌流减少，表现为妊娠期出现高血压、蛋