晚期胃癌的二线治疗课件

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1、晚期胃癌的二线治疗安徽省立医院肿瘤科胡冰HighincidenceAge-adjustedgastriccancerincidenceper100000HighincidenceHighlightstodayOverreviewoffirstlinetreatmentSecond-linetreatmentchemotherapypredicativefactorstargettherapypredicativefactorsOtherendpointsTakehomemessageHighlights

2、todayOverreviewoffirstlinetreatmentSecond-linetreatmentchemotherapypredicativefactorstargettherapypredicativefactorsOtherendpointsTakehomemessageOverreviewoffirstlinetreatmentOverreviewoffirstlinetreatmentOverreviewoffirstlinetreatmentOverreviewoffirstli

3、netreatmentOverreviewoffirstlinetreatmentHighlightstodayOverreviewoffirstlinetreatmentSecond-linetreatmentchemotherapypredicativefactorstargettherapypredicativefactorsOtherendpointsTakehomemessageSecond-linetreatmentFirst-linetreatmentSecond-linetreatmen

4、tPDBenefit?Second-linetreatmentSecond-linetreatment1.Irinotecanhasbeenshowntohaveactivityingastrointestinalcancers2.usedinasecond-linesettingformetastaticcoloncancer,eitheraloneorincombinationwithotheragents(eg,fuorouracil,bevacizumab,orcetuximab)Topoiso

5、meraseIinhibitorsLancet1998;352:1407-1412TopoisomeraseIinhibitorsMonotherapyJpnJCancerChemother1994;21:1033-38Tumori2003；89:405-07.TopoisomeraseIinhibitorsCombinationtherapyAnticancerRes2006;26:1595-1599AmJClinOncol2005;28:581-588JChemother2003;15:275-27

6、8TaxanesJClinOncol2006;24:4991-4997.Taxanes,whichbindandstabilisemicrotubulesleadingtocell-cyclearrest,havebeenusedinthefirst-linesettingforadvancedgastriccancer.TaxanesAnnOncol2000;11:1263-66AnticancerRes2003;23:4219-22CancerChemotherPharmacol2008;61:63

7、1-637PlatinumagentsPlatinumdrugsgivenaloneassecond-linereatmenthavefallenoutoffavourinadvancedgastriccancer,mainlyduetotheirfrequentuseinthefirst-linesetting2.However,itisstillreasonabletoconsidertheminpatientswhohavenotbeenpreviouslyexposedtoplatinumage

8、nts.PlatinumagentsMonotherapyEurJCancerClinOncol1985;21:1321-1324JpnJOncol1990;20:169-176PlatinumagentsCombinationtherapyAnnOncol2003;14:383-387.CancerChemotherPharmacol2008;63:433-39Fluorouracil-basedregimensDespitethefac