慢性骨髓炎负压封闭引流结合抗生素珠链植入与抗生素液灌洗引流治疗的比较研究

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1、[摘要]目的：探宄负压封闭引流结合抗生素珠链植入与抗生素液灌洗引流治疗慢性骨髓炎的临床疗效。方法：选择我院2015年1月-2016年1月收治的92例慢性骨髓炎患者为研究对象,按照住院号的奇偶数随机分为对照组和治疗组(各46例)。对照组给予常规抗生素液灌洗引流治疗；治疗组给予负压封闭引流结合抗生素球链楨入治疗。比较两组患者治疗后的功能恢复情况、复发率、再次清创率、治愈率、换药次数、使用抗生素时间、愈合时间、住院时间、细菌检出率；对所有患者进行随访并进行满意度调查。结果：所有患者均进行6〜18个月的随访，其中治疗纟II术后功能恢优良率以及治愈率分别为91.3%和95.7%，显著高于对照

2、组的67.4%和65.2%(P<0.01);治疗组的复发率、再次清创率以及细菌检山率均明S少于对照组(P<0.01)；治疗组换药次数、使用抗生素时间、愈合时间、住院时间以及满意率也明显优于对照组(P<0.01)o结论：负压封闭引流结合抗生素珠链植入治疗慢性骨髓炎，与传统抗生素液灌洗引流比较，不仅效果明显而且安全可靠，能有效提《患者生活质以，因此伉得应用和推广。[关键词]慢性骨髓炎；负压封闭引流；抗生素珠链祖入；抗生素液灌洗引流Acomparativestudyofnegativepressurecloseddrainagecombinedwithantibioticbeadsimp

3、lantationandantibioticliquidlavagedrainageonthetreatmentofchronicosteomyelitis[Abstract]Objective:Toexploretheclinicalefficacyofnegativepressurecloseddrainagecombinedwithantibioticbeadsimplantationandantibioticliquidlavagedrainageonthetreatmentofchronicosteomyelitis.Methods:92patientswithchron

4、icosteomyelitisadmittedinourhospitalfromJanuary,2015toJanuary,2016wereselectedassubjects,patientswererandomlydividedintocontrolgroupandtreatmentgroupaccordingtotheoddevennumberofhospitalized(eachof46cases).Thecontrolgroupwasgivenroutineantibioticliquidlavagedrainagefortreatment;Thetreatmentgro

5、upwasgivennegativepressurecloseddrainagecombinedwithantibioticbeadsimplantationfortreatment.Thefunctionrecovery,recurrencerate,debridementagainrate,curerate,dressingfrequency,antibioticusetime，healingtime,hospitalizationtime,bacterialdetectionrateaftertreatmentwerecomparedbetweenthetwogroupsof

6、patients;Allpatientswerefollowedupandsatisfactionwasinvestigated.Results:Allpatientswerefollowedupfor6to18months,theexcellentrateofrecoveryandthecurerateinthetreatmentgroupwere91.3%and95.7%，whichwassignificantlyhigherthanthatofthecontrolgroup(67.4%vs65.2%,P<0.01).Therecurrencerate，debridementr

7、ateandbacterialdetectionrateinthetreatmentgroupweresignificantlylessthanthoseinthecontrolgroup(P<0.01).Thetimesofdressing,timeofantibioticuse,healingtime,hospitalizationtimeandsatisfactionrateofthetreatmentgroupwerealsobetterthanthoseof