医学课件酮病ketosis in dairy

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1、酮病KetosisinDairyCattle1韩特博士Preparedby:Dr.TerryHuntBSc.DVMMRCVSDairyHerdHealthSpecialistChina–CanadaAnimalHealthInitiative2酮病Ketosis泌乳牛代谢病，体重下降、异食僻、食欲差、奶产量下降、神经官能异常Ketosisisametabolicdiseaseoflactatingcowscharacterizedbyweightloss,pica,decreasedappetite,decreasedmilkproductionandneu

2、rologicalabnormalities通常在产后六周出现Itgenerallyoccursinthefirstsixweeksoflactation.3续上Ketosiscont’d血液和组织伴有大量酮体：β-羟基丁酸、乙酰乙酸、丙酮ItischaracterizedbyanaccumulationinthebloodandtissuesoflargequantitiesofKetonebodies:B-hydroxybutyricacid,acetoaceticacidandacetone.酮体是肝内脂肪正常代谢产物Ketonebodiesareno

3、rmalproductsofthemetabolismoffatintheliver.45病因Cause摄入不充足能量形成的能量负平衡导致酮体产量增加NegativeenergybalancecausedbyinadequateenergyintakeleadingtoincreasedproductionofKetonebodies.伴有血糖过低Itisaccompaniedbyhypoglycemia6危险因素Riskfactors低能量摄入Lowenergyintake高蛋白摄入Highproteinintake青贮料过多（丁酸是前体物）Excessi

4、vesilage(butyricacidisprecursortoformationofKetonebodies)奶牛过肥Overfatcows7续上RiskFactorscont’d缺乏运动Lackofexercise继发性酮病Concurrentdiseaselimitingfeedintakecanleadtosecondaryketosis子宫炎、乳腺炎、乳牛热、跛行、皱胃移胃Metritis,Mastitis,MilkFever,Lameness,DisplacedAbomasum8临床症状ClinicalSigns消耗性综合症WastingSyn

5、drome渐进性发作Onsetisusuallygradual早期为饲料摄入轻微降低Earlysignsareaslightdecreaseinfeedintake奶产量下降Dropinmilk精神萎靡Lethargy粪表面有坚固粘液膜Firmmucouscoveredfeces9续上WastingSyndromecont’d体重下降Weightloss异食僻Pica弓背Humpedbackposture奶牛和尿酮体检测显阳性KetonuriaandpositiveRothera’stestinmilk呼出气体有酮味Ketonesmellonbreath10

6、续上ClinicalSignscont’d神经症状Nervoussyndrome突然发生Suddenonset行为异常1-2小时1-2hourepisodesofbizarrebehavior吼叫Bellowing转圈Circling11续上NervousSyndromecont’d用头抵压Headpressing徘徊Aimlesswandering食欲异常Abnormalappetite共济失调Incoordination12续前ClinicalSignscont’d亚临床酮病Sub-clinicalketosis仅吃粗料，不食精料Eatroughageb

7、utnotconcentrate体重下降Weightloss/conditionloss奶产量下降Decreasedmilkyield酮尿Ketonuria低繁殖、卵巢功能紊乱、子宫内膜炎Reducedfertility,ovariandysfunctionandendometritis13鉴别诊断DifferentialDiagnosis消瘦性综合症WastingSyndrome肥牛综合症FatCowSyndrome移胃DisplacedAbomasum消化不良Indigestion(Acidosis)Pylonephritis创伤性网胃炎Hardware

8、Disease14续前DifferentialDia